| Effect of selenium on hypothyroidism induced by methimazole (MMI) in lactating rats and their pups. | |
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MedLine Citation:
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PMID: 20519169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was undertaken to assess the effect of selenium (Se) on hypothyroidism induced by methimazole (MMI) in lactating rats and their pups. Rats were randomly divided into four groups of six each: group I served as a negative control which received standard diet; group II received orally MMI (250 mg L -1 ); group II received both MMI (250 mg L -1 , orally) and Se (0.5 mg/kg of diet); group IV served as a positive control and received Se (0.5 mg Na 2 SeO 3 /kg of diet). Treatments were started from the 14th day of pregnancy until postnatal day 14. In the MMI-exposed group, the body weight of 14-day-old pups diminished compared to controls; besides, a hypertrophy of the thyroid glands was observed. Co-administration of Se through the diet restored these parameters to near normal values. In the MMI-treated group, thyroid iodine contents and plasma thyroid hormone levels significantly decreased, while plasma TSH levels increased in pups and their mothers. These biochemical modifications corresponded histologically to closed follicles, increased vascularity and a reduction in colloid volume. Co-treatment with Se ameliorated these parameters. We concluded that the supplementation of Se in diet had beneficial effects on hypothyroidism during a critical period of life. |
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Authors:
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Ibtissem Ben Amara; Hanen Bouaziz; Fadhel Guermazi; Najiba Zeghal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta biologica Hungarica Volume: 61 ISSN: 0236-5383 ISO Abbreviation: Acta. Biol. Hung. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-03 Completed Date: 2010-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8404358 Medline TA: Acta Biol Hung Country: Hungary |
Other Details:
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Languages: eng Pagination: 145-57 Citation Subset: IM |
Affiliation:
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Sfax Faculty of Science Department of Life Sciences, Animal Physiology Laboratory BP 1171 3000 Sfax Tunisia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antithyroid Agents / pharmacology* Feeding Behavior / drug effects Female Humans Hypertrophy / pathology Hypothyroidism / drug therapy* Lactation / drug effects* Male Maternal Exposure Methimazole / pharmacology* Pregnancy Rats Rats, Wistar Selenium / chemistry, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antithyroid Agents; 60-56-0/Methimazole; 7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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