Document Detail

Effect of selenium-deficient diet in experimental glomerular disease.
MedLine Citation:
PMID:  1636744     Owner:  NLM     Status:  MEDLINE    
We examined the effect of a selenium-deficient diet on two experimental models of glomerular disease, the puromycin aminonucleoside (PAN)-induced nephrotic syndrome, a model of minimal change disease, and passive Heymann nephritis, a complement-dependent and neutrophil-independent model that resembles membranous nephropathy. The specific activity of selenium-dependent glutathione peroxidase was markedly reduced in the liver, the kidney cortex, and in glomeruli in weanling male Sprague-Dawley rats placed on a selenium-deficient diet for 6 wk compared with rats fed a selenium-replete diet, with no significant differences in the specific activities of superoxide dismutase or catalase. PAN-injected selenium-deficient rats had a marked and significantly greater proteinuria throughout the course of the experiment compared with PAN-injected selenium-replete rats with no significant histological differences. In the passive Heymann nephritis model induced by injecting anti-Fx1A immunoglobulin G, rats fed a selenium-deficient diet had significantly higher urinary protein (day 5: 91 +/- 16 mg/24 h, n = 10) compared with rats fed a selenium-replete diet (52 +/- 5 mg/24 h, n = 11) with no differences in the amount of antibody deposited in the kidney. The most likely explanation for the effect of a selenium-deficient diet is that selenium deficiency resulted in a marked reduction of glutathione peroxidase, thus indicating an important role of glutathione peroxidase in these models of glomerular injury.
R Baliga; M Baliga; S V Shah
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  263     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-24     Completed Date:  1992-08-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  F56-61     Citation Subset:  IM    
Department of Pediatrics, Louisiana State University School of Medicine, New Orleans 70112.
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MeSH Terms
Antibodies, Anti-Idiotypic / immunology
Glutathione Peroxidase / metabolism
Immunoglobulin G / immunology
Kidney Cortex / enzymology
Kidney Diseases / enzymology
Kidney Glomerulus* / enzymology
Liver / enzymology
Nephrotic Syndrome / chemically induced,  enzymology
Proteinuria / enzymology,  immunology
Puromycin Aminonucleoside
Selenium / administration & dosage*,  deficiency
Grant Support
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 0/Immunoglobulin G; 58-60-6/Puromycin Aminonucleoside; 7782-49-2/Selenium; EC Peroxidase

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