| Effect of selenium-deficient diet in experimental glomerular disease. | |
| | |
MedLine Citation:
|
PMID: 1636744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We examined the effect of a selenium-deficient diet on two experimental models of glomerular disease, the puromycin aminonucleoside (PAN)-induced nephrotic syndrome, a model of minimal change disease, and passive Heymann nephritis, a complement-dependent and neutrophil-independent model that resembles membranous nephropathy. The specific activity of selenium-dependent glutathione peroxidase was markedly reduced in the liver, the kidney cortex, and in glomeruli in weanling male Sprague-Dawley rats placed on a selenium-deficient diet for 6 wk compared with rats fed a selenium-replete diet, with no significant differences in the specific activities of superoxide dismutase or catalase. PAN-injected selenium-deficient rats had a marked and significantly greater proteinuria throughout the course of the experiment compared with PAN-injected selenium-replete rats with no significant histological differences. In the passive Heymann nephritis model induced by injecting anti-Fx1A immunoglobulin G, rats fed a selenium-deficient diet had significantly higher urinary protein (day 5: 91 +/- 16 mg/24 h, n = 10) compared with rats fed a selenium-replete diet (52 +/- 5 mg/24 h, n = 11) with no differences in the amount of antibody deposited in the kidney. The most likely explanation for the effect of a selenium-deficient diet is that selenium deficiency resulted in a marked reduction of glutathione peroxidase, thus indicating an important role of glutathione peroxidase in these models of glomerular injury. |
| | |
Authors:
|
R Baliga; M Baliga; S V Shah |
Related Documents
:
|
16520934 - Study of the bioavailability of selenium in cows' milk after a supplementation of cow f... 4028004 - Long-term persistence of ethyl carbamate-induced sister chromatid exchanges in murine l... 23532144 - Dietary supplementation of high-performance korean and japanese judoists. 18567064 - Cross-cultural differences in the macronutrient intakes of women with anorexia nervosa ... 22436224 - The potential use of n-alkanes, long-chain alcohols and long-chain fatty acids as diet ... 16274334 - Use of the ketogenic diet as a treatment for epilepsy refractory to drug treatment. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of physiology Volume: 263 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1992 Jul |
Date Detail:
|
Created Date: 1992-08-24 Completed Date: 1992-08-24 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: F56-61 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Louisiana State University School of Medicine, New Orleans 70112. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibodies, Anti-Idiotypic / immunology Diet Glutathione Peroxidase / metabolism Immunoglobulin G / immunology Kidney Cortex / enzymology Kidney Diseases / enzymology Kidney Glomerulus* / enzymology Liver / enzymology Male Nephrotic Syndrome / chemically induced, enzymology Proteinuria / enzymology, immunology Puromycin Aminonucleoside Rats Selenium / administration & dosage*, deficiency |
| Grant Support | |
ID/Acronym/Agency:
|
R01-DK-41480/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Anti-Idiotypic; 0/Immunoglobulin G; 58-60-6/Puromycin Aminonucleoside; 7782-49-2/Selenium; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of formate and oxalate on volume absorption in rat proximal tubule.
Next Document: Functional and structural characterization of endosomes from toad bladder epithelial cells.