| Effect of selegiline and desmethyl-selegiline on cortical electric activity in rats. | |
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MedLine Citation:
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PMID: 2128497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pharmaco-EEG changes caused by the monoamine oxidase (MAO) B inhibitor selegiline were compared with the frequency band alterations aroused by its desmethyl metabolite after oral administration in rats. After single administration (5 mg/kg) the EEG changes caused by selegiline or desmethyl-selegiline differed significantly. Distinct decreases in delta and clear increases in theta EEG frequency bands were obvious after administration of selegiline. The single oral dose of desmethyl-selegiline (5 mg/kg) caused only trendly the same EEG changes observed after giving the mother compound. Following repeated administration on four consecutive days no significant differences in the frequency band changes could be seen after selegiline or desmethyl-selegiline. Based on present results it is likely that the mode of action of desmethyl-selegiline appears to be similar or identical with the mode of action of the parent compound, selegiline. |
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Authors:
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B Nickel; H O Borbe; I Szelenyi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neural transmission. Supplementum Volume: 32 ISSN: 0303-6995 ISO Abbreviation: J. Neural Transm. Suppl. Publication Date: 1990 |
Date Detail:
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Created Date: 1991-05-29 Completed Date: 1991-05-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0425126 Medline TA: J Neural Transm Suppl Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 139-44 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, ASTA Pharma AG, Frankfurt/Main, Federal Republic of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amphetamines
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pharmacology* Animals Cerebral Cortex / drug effects* Electroencephalography* Female Fourier Analysis Rats Rats, Inbred Strains Selegiline / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Amphetamines; 14611-51-9/Selegiline; 18913-84-3/desmethylselegiline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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