Document Detail


Effect of selective thromboxane synthetase inhibitor on vein grafts.
MedLine Citation:
PMID:  3686135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the effect of a selective thromboxane synthetase inhibitor (TSI) on the patency of autogenous vein grafts in dogs. Treatment involved oral dosing (10 mg/kg bid) of TSI or placebo, combined with local treatment of the graft with TSI or placebo (papavarine) at the time of implantation. At harvest, two animals, one from each oral dosing group, had an occluded graft; both grafts had been locally treated with papavarine. We found no significant histopathologic difference between graft treatment groups. Attempts to estimate the effect of TSI dosing on the prostacyclin/thromboxane balance through radioimmunoassay analysis of graft perfusates were unsuccessful. As measured by in vitro platelet aggregation, oral TSI was found to alter platelet function, though not in a dose-dependent fashion, and the animals rebounded toward normal at 12 hours.
Authors:
M Cargile; S L Neyman; R F Hebeler; R Askins; J P O'Leary
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  80     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-21     Completed Date:  1987-12-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1355-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Baylor University Medical Center, Dallas, Tex. 75246.
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzofurans / pharmacology*
Blood Vessel Prosthesis*
Dogs
Graft Occlusion, Vascular / prevention & control*
Iliac Artery / surgery
Jugular Veins / transplantation*
Male
Platelet Aggregation / drug effects
Thromboxane-A Synthase / antagonists & inhibitors*
Vascular Patency / drug effects*
Chemical
Reg. No./Substance:
0/Benzofurans; 85666-17-7/furegrelate; EC 5.3.99.5/Thromboxane-A Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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