Document Detail


Effect of a selective rise in sinusoidal norepinephrine on HGP is due to an increase in glycogenolysis.
MedLine Citation:
PMID:  9458762     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the effect of a selective rise in liver sinusoidal norepinephrine (NE) on hepatic glucose production (HGP), norepinephrine (50 ng.kg-1.min-1) was infused intraportally (Po-NE) for 3 h into five 18-h-fasted conscious dogs with a pancreatic clamp. In the control protocol, NE (0.2 ng.kg-1.min-1) and glucose were infused peripherally to match the arterial NE and blood glucose levels in the Po-NE group. Hepatic sinusoidal NE levels rose approximately 30-fold in the Po-NE group but did not change in the control group. The arterial NE levels did not change significantly in either group. During the portal NE infusion, HGP increased from 1.9 +/- 0.2 to 3.5 +/- 0.4 mg.kg-1.min-1 (15 min; P < 0.05) and then gradually fell to 2.4 +/- 0.4 mg.kg-1.min-1 by 3 h. HGP in the control group did not change (2.0 +/- 0.2 to 2.0 +/- 0.2 mg.kg-1.min-1) for 15 min but then gradually fell to 1.1 +/- 0.2 mg.kg-1.min-1 by the end of the study. Because the fall in HGP from 15 min on was parallel in the two groups, the effect of NE on HGP (the difference between HGP in the two groups) did not decline over time. Gluconeogenesis did not change significantly in either group. In conclusion, elevation in hepatic sinusoidal NE significantly increases HGP by selectively stimulating glycogenolysis. Compared with the previously determined effects of epinephrine or glucagon on HGP, the effect of NE is, on a molar basis, less potent but more sustained over time.
Authors:
C A Chu; D K Sindelar; D W Neal; E J Allen; E P Donahue; A D Cherrington
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  274     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-19     Completed Date:  1998-02-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E162-71     Citation Subset:  IM    
Affiliation:
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / blood
Animals
Blood Glucose / metabolism
Dogs
Epinephrine / blood
Fatty Acids, Nonesterified / blood
Female
Glucagon / blood
Gluconeogenesis / drug effects*
Glucose / administration & dosage,  pharmacology
Glycerol / blood
Infusions, Intravenous
Insulin / blood
Kinetics
Lactates / blood
Liver / drug effects,  metabolism*
Liver Glycogen / metabolism*
Male
Norepinephrine / administration & dosage,  blood,  pharmacology*
Pancreas / physiology
Portal System
Grant Support
ID/Acronym/Agency:
2RO1 DK-18243/DK/NIDDK NIH HHS; 5P60 DK-20593/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Lactates; 0/Liver Glycogen; 11061-68-0/Insulin; 50-99-7/Glucose; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 56-81-5/Glycerol; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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