Document Detail


Effect of selective hepatic vagotomy on plasma FFA levels in resting and exercising rats.
MedLine Citation:
PMID:  3354708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Metabolic effects of a selective hepatic vagotomy (HV) were investigated in nonfasted (N) and 24-h fasted (F) rats, at rest and immediately after a 50-min exercise period (26 m/min, 0% grade). In nonfasted rats, no significant differences between HV and sham-operated (SHM) groups were found in blood substrates [free fatty acids (FFA) or glucose], insulin, and muscle glycogen levels, either at rest or after exercise. In F rats, liver glycogen was almost completely depleted at rest. This depletion was associated with a significantly (P less than 0.05) lower plasma FFA concentration at rest in HV compared with SHM rats (mean +/- SE, 0.57 +/- 0.04 vs. 0.83 +/- 0.1 mmol/l). No differences in FFA levels were observed between the same two groups after the exercise period. Exercise, however, resulted in a 2.5 times greater glycogen breakdown in the soleus muscle of HV compared with SHM rats. Hepatic vagotomy in the F condition was also associated with lower resting and exercising insulin concentrations. It is concluded that HV, when followed by a 24-h fast, may influence metabolic substrate regulation at rest and to a certain extent during exercise. These data support the concept of the existence of hepatic glucoreceptors responsive to a decrease in liver glycogen content.
Authors:
J M Lavoie; M Lord; A Paulin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  254     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-05-12     Completed Date:  1988-05-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R602-6     Citation Subset:  IM    
Affiliation:
Département d'Education Physique, Université de Montréal, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Fasting
Fatty Acids, Nonesterified / blood*
Liver / innervation*
Male
Physical Exertion*
Rats
Rats, Inbred Strains
Reference Values
Vagotomy*
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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