| Effect of a selective 5-HT3 receptor agonist on gastric motility in fasted and fed dogs. | |
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MedLine Citation:
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PMID: 9200559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of m-chlorophenylbiguanide, a selective 5-HT3 receptor agonist, on gastric antral motility was investigated in conscious dogs with a force transducer implanted chronically. m-Chlorophenylbiguanide (0.1-1 mg/kg i.v.) dose dependently enhanced antral motility in the fasted state, and the amplitude of m-chlorophenylbiguanide (1 mg/kg i.v.)-induced antral contractions reached the level of natural phase III contractions. In contrast, m-chlorophenylbiguanide reduced the amplitude of antral contractions in the fed state. A selective 5-HT3 receptor antagonist, ramosetron (0.0003-0.03 mg/kg i.v.), inhibited both effects of m-chlorophenylbiguanide. m-Chlorophenylbiguanide (1 mg/kg i.v.)-induced contractions were inhibited by atropine (0.03 or 0.1 mg/kg i.v.). These results indicate that pharmacological activation of 5-HT3 receptors has opposite effects on canine gastric antral motility in the fasted and in the fed state, being stimulatory and inhibitory, respectively. The stimulatory effect seems to be mediated mainly via the release of acetylcholine. |
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Authors:
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Y Nagakura; H Ito; T Kamato; A Nishida; K Miyata |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 327 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-08-18 Completed Date: 1997-08-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 189-93 Citation Subset: IM |
Affiliation:
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Pharmacological Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd., Tsukuba, Ibaraki, Japan. nagakura@yamanouchi.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzimidazoles / pharmacology* Biguanides / pharmacology* Dogs Fasting Gastrointestinal Motility / drug effects* Male Serotonin Agonists / pharmacology* Stomach / drug effects*, physiology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Benzimidazoles; 0/Biguanides; 0/Serotonin Agonists; 132907-72-3/ramosetron; 48144-44-1/1-(3-chlorophenyl)biguanide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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