Document Detail


Effect of seizure on hippocampus in mesial temporal lobe epilepsy and neocortical epilepsy: an MRS study.
MedLine Citation:
PMID:  16158277     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was performed to evaluate the effect of seizures on the bilateral hippocampus in mesial temporal lobe epilepsy (mTLE) and neocortical epilepsy by single voxel proton magnetic resonance spectroscopy (MRS). Forty-one patients with mTLE having unilateral hippocampal sclerosis and 43 patients with a neocortical epilepsy who underwent subsequent epilepsy surgery were recruited. Ninety-five percent confidence intervals of N-acetyl aspartate/choline (NAA/Cho) and NAA/creatine (NAA/Cr) ratios in 20 healthy control subjects were used as threshold values to determine abnormal NAA/Cho and NAA/Cr. NAA/Cho and NAA/Cr were significantly lower in the ipsilateral hippocampus of mTLE and neocortical epilepsy. Using asymmetry indices for patients with bilaterally abnormal ratios of NAA/Cho and NAA/Cr in addition to using unilateral abnormal ratio, the seizure focus was correctly lateralized in 65.9% of patients with mTLE and 48.8% of neocortical epilepsy patients. Bilateral NAA/Cho abnormality was significantly related to a poor surgical outcome in mTLE. No significant relationship was found between the results of NAA/Cho or NAA/Cr and surgical outcome in neocortical epilepsy. The mean contralateral NAA/Cr ratio of the hippocampus in mTLE was significantly lower in patients with a history of secondary generalized tonic-clonic seizure (SGTCS) than in those without. Our results demonstrate effects of seizures on the hippocampi in neocortical epilepsy and the relation between SGTCS and NAA/Cr of the contralateral hippocampus in mTLE. This proves the presence of a seizure effect on the hippocampus in neocortical epilepsy as well as in mTLE.
Authors:
S K Lee; D W Kim; K K Kim; C K Chung; I C Song; K H Chang
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Publication Detail:
Type:  Journal Article     Date:  2005-09-13
Journal Detail:
Title:  Neuroradiology     Volume:  47     ISSN:  0028-3940     ISO Abbreviation:  Neuroradiology     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-01     Completed Date:  2006-03-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  916-23     Citation Subset:  IM    
Affiliation:
Department of Neurology, Seoul National University College of Medicine, Seoul National University Hospital, Chongno ku, Korea. sangunlee@dreamwiz.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aspartic Acid / analogs & derivatives,  analysis
Case-Control Studies
Choline / analysis
Epilepsy, Temporal Lobe / complications*
Female
Hippocampus / pathology*,  physiology*,  radionuclide imaging
Humans
Magnetic Resonance Spectroscopy
Male
Neocortex / pathology
Protons
Seizures / complications*
Chemical
Reg. No./Substance:
0/Protons; 56-84-8/Aspartic Acid; 62-49-7/Choline; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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