| Effect of sedation with detomidine on intraocular pressure with and without topical anesthesia in clinically normal horses. | |
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MedLine Citation:
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PMID: 22256847 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective-To determine the effect of sedation with detomidine on intraocular pressure (IOP) in standing horses and whether topical ocular application of anesthetic alters this effect. Design-Clinical trial. Animals-15 clinically normal horses. Procedures-Horses were assigned to group 1 (n = 7) or 2 (8). Intraocular pressure measurements were obtained at baseline (before sedation) and 10 minutes after IV administration of detomidine (0.02 mg/kg [0.009 mg/lb]). Group 1 horses had an additional IOP measurement at 20 minutes after sedation. For group 2 horses, topical ocular anesthetic was administered 10 minutes prior to baseline IOP measurements. Results-Mean ± SD baseline IOP for horses without topical anesthesia (group 1 horses; IOP, 24.30 ± 3.09 mm Hg) was significantly lower, compared with that of horses with topical anesthesia (group 2 horses; IOP, 30.40 ± 3.25 mm Hg). Compared with baseline values, IOP at 10 minutes after sedation decreased significantly in all horses (by 3.61 ± 1.48 mm Hg and 5.78 ± 4.32 mm Hg in groups 1 and 2, respectively). In group 1 horses, IOP at 10 (20.69 ± 3.45 mm Hg) and 20 (19.96 ± 2.13 mm Hg) minutes after sedation was significantly decreased, compared with baseline values; however, the difference between IOP at 10 versus 20 minutes was not significant. The difference in IOP between group 1 and 2 horses at 10 minutes after sedation was not significant. Conclusions and Clinical Relevance-IV administration of detomidine caused a decrease in IOP in clinically normal horses and may be a safe sedative when performing ocular procedures. |
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Authors:
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Dana L Holve |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Veterinary Medical Association Volume: 240 ISSN: 1943-569X ISO Abbreviation: J. Am. Vet. Med. Assoc. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503067 Medline TA: J Am Vet Med Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 308-11 Citation Subset: IM |
Affiliation:
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From Eye Care for Animals, 3025 Edinger Ave, Tustin, CA 92780. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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