| Effect of second pregnancy on maternal carriage and outcome of high-risk human papillomavirus (HPV). Experience from the prospective finnish family HPV study. | |
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MedLine Citation:
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PMID: 19287178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The effect of second pregnancy on human papillomavirus (HPV) carriage and outcome is modelled in longitudinal setting covering two subsequent pregnancies. STUDY DESIGN: Among 329 (baseline pregnant) women prospectively followed up in the Finnish Family HPV Study, two subcohorts were compiled: (i) 78 women (Group B) who became pregnant for the second time during the follow-up, and (ii) 100 women (Group A) who did not develop 2nd pregnancy. The effect of pregnancy on high-risk HPV (HR-HPV) carriage and outcome was analysed using Kaplan-Meier and Cox survival analyses and generalized estimating equation (GEE) modelling of the longitudinal data. RESULTS: Women in the two groups were similar in their baseline HR-HPV status but significantly different in several known risk factors of HR-HPV infection. Group A women showed higher point prevalence of cervical and oral HR-HPV at the 36-month (p = 0.015) and 6-month (p = 0.024) follow-up visit, respectively. Among Group B women, prevalence of both cervical and oral HR-HPV significantly decreased during 2nd pregnancy (p = 0.005 and p = 0.002) as compared with inter-pregnancy period, but increased again after 2nd pregnancy. There was no difference in acquisition or clearance of cervical or oral HR-HPV between the two groups in univariate (Kaplan-Meier) or multivariate (Cox) survival analysis. In the GEE approach, 2nd pregnancy was not significantly associated with cervical or oral HR-HPV carriage or persistence when adjusted for all other covariates. CONCLUSIONS: Second pregnancy is of little impact on carriage and persistence of oral and cervical HR-HPV infections in a longitudinal setting over time. |
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Authors:
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Marja E Sarkola; Seija E Grénman; Marjut A M Rintala; Kari J Syrjanen; Stina M Syrjanen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-16 |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 67 ISSN: 1423-002X ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-04-17 Completed Date: 2009-08-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: Switzerland |
Other Details:
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Languages: eng Pagination: 208-16 Citation Subset: IM |
Copyright Information:
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Copyright 2008 S. Karger AG, Basel. |
Affiliation:
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Department of Obstetrics and Gynaecology, Turku University Hospital, Turku, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alphapapillomavirus Carrier State Female Finland Humans Longitudinal Studies Papillomavirus Infections / epidemiology* Parity* Pregnancy Pregnancy Complications, Infectious / epidemiology* Risk Factors Uterine Cervical Neoplasms / epidemiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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