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Effect of salvianolic Acid B and paeonol on blood lipid metabolism and hemorrheology in myocardial ischemia rabbits induced by pituitruin.
MedLine Citation:
PMID:  21152295     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine the therapeutic effect of salvianolic acid b and paeonol on coronary disease. The ischemia myocardial animal model is induced by administering pituitrin (20 μg·kg(-1)) intravenously via the abdominal vein. A combination of salvianolic acid b and paeonol (CSAP) (5, 10 and 15 mg/kg BW) was administrated to experimental rabbits. Biochemical indices were evaluated during six weeks of intervention. We found that the compound of salvianolic acid b and paeonol (5, 10 and 15 mg/kg BW) can markedly and dose-dependently reduce fibrinogen and malonaldehyde levels, increase the HDL level, improve blood viscosity and plasma viscosity in rabbits. In addition, the medicine can still reduce the ratio of NO/ET and the contents of lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) in a dose-dependent manner. This study demonstrates that compound of salvianolic acid b and paeonol (5, 10 and 15 mg/kg BW) can improve the blood hemorrheology, decrease oxidative injury and repair the function of blood vessel endothelium, and subsequently prevent the development of Coronary disease.
Authors:
Qian Yang; Siwang Wang; Yanhua Xie; Jianbo Wang; Hua Li; Xuanxuan Zhou; Wenbo Liu
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Publication Detail:
Type:  Journal Article     Date:  2010-09-28
Journal Detail:
Title:  International journal of molecular sciences     Volume:  11     ISSN:  1422-0067     ISO Abbreviation:  Int J Mol Sci     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101092791     Medline TA:  Int J Mol Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3696-704     Citation Subset:  -    
Affiliation:
Institute of Materia Medica, School of pharmacy; Fourth Military Medical University, Xi'an, Shaanxi, 7l0032, China; E-Mails: yanqian379@163.com (Q.Y.); xieyanh@fmmu.edu.cn (Y.X.); wangjp@fmmu.edu.cn (J.W.); 561641505@qq.com (H.L.); yunyaorao@sina.com (X.Z.).
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