Document Detail

Effect of saline infusions on intrarenal distribution of glomerular filtrate and proximal reabsorption in the dog.
MedLine Citation:
PMID:  5545118     Owner:  NLM     Status:  MEDLINE    
The effect of acute extracellular volume expansion with saline on the intrarenal distribution of glomerular filtrate, was studied in dogs utilizing micropuncture techniques in which samples were obtained by both recollection and from new tubules. Recollection was examined in seven dogs during continuous hydropenia and in five dogs during continuous saline diuresis. Recollection was associated with an increase in nephron flow rate of 8% during hydropenia and 27% during saline diuresis. In addition, during continuous saline diuresis, shortened transit times and lowered intratubular pressures were recorded in previously punctured tubules. Despite increased tubular flow, fractional reabsorption was unchanged. Nephron glomerular filtration rates (gfr) were measured during hydropenia and then after acute volume expansion in 10 dogs. In the repunctured tubules gfr rose 38% more than total glomerular filtration rate (GFR). In contrast, when new tubules were punctured during volume expansion, nephron gfr and total GFR changed proportionately. The disproportionate rise in nephron gfr after volume expansion noted with the recollection technique appears to be artifactual when contrasted to micropuncture of new tubules. With acute volume expansion, fractional reabsorption decreased 15% in recollected samples and 16% in newly sampled tubules. Increased nephron gfr cannot account for the fall in fractional reabsorption. It is concluded that in dogs, saline diuresis is not associated with redistribution of filtrate from deep to superficial nephrons, and that the fall in proximal fractional reabsorption is caused by diminished absolute reabsorption.
H Mandin; A H Israelit; F C Rector; D W Seldin
Related Documents :
25107578 - Effects of exercise rehabilitation on cardiac electrical instability assessed by t-wave...
22880108 - The effect of exercise training modality on serum brain derived neurotrophic factor lev...
17566888 - Urinary excretion of kaempferol from common beans (phaseolus vulgaris l.) in humans.
14734158 - Oxalobacter formigenes and its role in oxalate metabolism in the human gut.
6453568 - Myofascial trigger point syndromes: an approach to management.
22460178 - Community-based exercise and wellness program for people diagnosed with parkinson disea...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  50     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1971 Mar 
Date Detail:
Created Date:  1971-04-06     Completed Date:  1971-04-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  514-22     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Dehydration / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Glutathione biosynthesis in human erythrocytes. I. Identification of the enzymes of glutathione synt...
Next Document:  Influence of scar on left ventricular performance at the onset of myocardial ischemia: shock versus ...