Document Detail

Effect of salicylate on upper airway stability and pressure flow: relationship in anesthetized dogs.
MedLine Citation:
PMID:  2909655     Owner:  NLM     Status:  MEDLINE    
Previous studies have shown that upper airway muscle activity is augmented in response to increased respiratory drive, thereby improving upper airway patency. In the present study we evaluated the effect of salicylate, a well-known respiratory stimulant, on upper airway stability and pressure-flow relationship. Multiple levels of airflow were used to assess pressure-flow relationship in the isolated airways of anesthetized dogs and to calculate the coefficients of Rohrer's equation P = K1V + K2V2. In addition, we measured the negative intraluminal pressure needed to collapse the upper airway. These measurements were repeated after intravenous administration of sodium salicylate, 250 mg/kg. Salicylate-induced hyperventilation was associated with increased alae nasi electrical activity. Resistance to airflow and K2 decreased significantly (p less than 0.01), suggesting dilation of the upper airway lumen. The intraluminal pressure under which upper airway collapse occurred became more negative in all dogs (from -5.0 +/- 0.8 to -8.5 +/- 1.3 cm H2O, p less than 0.01), indicating improved stability of the upper airway walls. These findings suggest that salicylate, and presumably other pharmacologic agents that stimulate ventilation, can improve both upper airway patency and upper airway stability.
A Oliven; M Odeh; N Gavriely
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  113     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-09     Completed Date:  1989-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8-14     Citation Subset:  AIM; IM    
Department of Medicine B, Haifa City Medical Center (Rothschild), Israel.
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MeSH Terms
Airway Resistance / drug effects*
Respiration / drug effects
Salicylic Acid
Salicylic Acids / pharmacology*
Sleep Apnea Syndromes / drug therapy
Reg. No./Substance:
0/Salicylic Acids; 69-72-7/Salicylic Acid

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