Document Detail


Effect of salicylate on normal and digoxin-intoxicated isolated rabbit heart.
MedLine Citation:
PMID:  6518339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The action of sodium salicylate on normal and digoxin-intoxicated rabbit heart was studied by the Langendorff perfusion method. The drug depressed heart rate, atrioventricular (AV) conduction and contraction force in the normal heart, and reversibly blocked the ventricular pacemakers induced by digoxin intoxication, whereas its effect on sinoatrial frequency as well as AV conduction was potentiated by digoxin. All the effects of sodium salicylate were stronger at pH 7.0 and weaker at pH 7.4, when compared to those at pH 7.2.
Authors:
M A Perez; A V Sarabanda; W L Padilha; M O Masuda
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  17     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  1984  
Date Detail:
Created Date:  1985-03-08     Completed Date:  1985-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  189-96     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Digoxin / toxicity*
Drug Synergism
Heart / drug effects*
Heart Conduction System / drug effects
Heart Rate / drug effects
Myocardial Contraction / drug effects
Perfusion
Rabbits
Sodium Salicylate / pharmacology*
Chemical
Reg. No./Substance:
20830-75-5/Digoxin; 54-21-7/Sodium Salicylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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