Document Detail

Effect of saccharin on growth and acid production of glucose-grown pathogenic and oral bacteria.
MedLine Citation:
PMID:  4033457     Owner:  NLM     Status:  MEDLINE    
Growth and acid production of glucose-grown Gram-positive and Gram-negative rods as well as cocci from the human oral cavity were studied in the presence of 0.02 to 20.00 mg/ml sodium saccharin. All Gram-positive rods, i.e. Actinomyces viscosus, Lactobacillus acidophilus, Bacillus subtilis and Corynebacterium diphtheriae, and Gram-positive cocci, i.e. Streptococcus spp, Staphylococcus aureus and Micrococcus luteus, were significantly inhibited by saccharin, especially at the higher concentrations. While Gram-negative cocci, i.e. Veillonella sp and Neisseria sicca were strongly inhibited by all tested saccharin concentrations, Gram-negative rods, i.e. the enterics and Acinetobacter sp, exhibited little if any inhibition. Saccharin caused a significant reduction in fermentative acid production congruent with observed growth.
H A Linke; G A Doyle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Microbios     Volume:  42     ISSN:  0026-2633     ISO Abbreviation:  Microbios     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-01     Completed Date:  1985-10-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207257     Medline TA:  Microbios     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  163-73     Citation Subset:  IM    
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MeSH Terms
Fermentation / drug effects
Glucose / metabolism*
Gram-Negative Bacteria / drug effects*,  growth & development,  metabolism
Gram-Positive Bacteria / drug effects*,  growth & development,  metabolism
Hydrogen-Ion Concentration
Mouth / microbiology
Saccharin / pharmacology*
Reg. No./Substance:
50-99-7/Glucose; 81-07-2/Saccharin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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