| Effect of saccharin on growth and acid production of glucose-grown pathogenic and oral bacteria. | |
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MedLine Citation:
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PMID: 4033457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Growth and acid production of glucose-grown Gram-positive and Gram-negative rods as well as cocci from the human oral cavity were studied in the presence of 0.02 to 20.00 mg/ml sodium saccharin. All Gram-positive rods, i.e. Actinomyces viscosus, Lactobacillus acidophilus, Bacillus subtilis and Corynebacterium diphtheriae, and Gram-positive cocci, i.e. Streptococcus spp, Staphylococcus aureus and Micrococcus luteus, were significantly inhibited by saccharin, especially at the higher concentrations. While Gram-negative cocci, i.e. Veillonella sp and Neisseria sicca were strongly inhibited by all tested saccharin concentrations, Gram-negative rods, i.e. the enterics and Acinetobacter sp, exhibited little if any inhibition. Saccharin caused a significant reduction in fermentative acid production congruent with observed growth. |
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Authors:
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H A Linke; G A Doyle |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Microbios Volume: 42 ISSN: 0026-2633 ISO Abbreviation: Microbios Publication Date: 1985 |
Date Detail:
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Created Date: 1985-10-01 Completed Date: 1985-10-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0207257 Medline TA: Microbios Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 163-73 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Fermentation
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drug effects Glucose / metabolism* Gram-Negative Bacteria / drug effects*, growth & development, metabolism Gram-Positive Bacteria / drug effects*, growth & development, metabolism Humans Hydrogen-Ion Concentration Mouth / microbiology Saccharin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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50-99-7/Glucose; 81-07-2/Saccharin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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