| Effect of the rs168924 Single-Nucleotide Polymorphism in the SLC6A2 Catecholamine Transporter Gene on Blood Pressure in Caucasians. | |
| | |
MedLine Citation:
|
PMID: 22533655 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
J Clin Hypertens (Greenwich). 2012; 14:293-298. ©2012 Wiley Periodicals, Inc. The NG_016969.1:g.5003A>G promoter polymorphism (rs168924) in the SLC6A2 norepinephrine transporter gene was found to be predictive of the hypertensive status in a Japanese population, but no data are available for Caucasians. Genotyping for rs168924 was performed in 282 young men with normal blood pressure (BP), grade 1 or 2 hypertension. In addition to casual BP, 24-hour ABPM and echocardiography were performed. Multiple regression analysis revealed a significant association of rs168924 genotype with diagnosis of hypertension (P=.044), casual systolic BP (SBP) levels (P=.028), and daytime ambulatory SBP (P=.02). The finding that rs168924 was also significantly associated with diastolic posterior wall thickness (P=.041), an echocardiographic index of hypertensive cardiac target organ damage, further supports the notion that the rs168924 SNP in SLC6A2 in fact might influence BP. Unlike previous findings in a Japanese population, in our Caucasian study cohort the presence of the minor rs168924 G allele was associated with lower prevalence of hypertension. J Clin Hypertens (Greenwich). 2012;00:00-00. ©2012 Wiley Periodicals, Inc. |
| | |
Authors:
|
Oliver Zolk; Christian Ott; Martin F Fromm; Roland E Schmieder |
Related Documents
:
|
22433975 - The difference in blood pressure readings between arms and survival: primary care cohor... 22577455 - Nifedipine, captopril or sublingual nitroglycerin, which can reduce blood pressure the ... 11699075 - Beat-to-beat evaluation of cardiac function in low-dose endotoxemia using a conscious s... 12715085 - Standardization of an isolated pig heart preparation with parabiotic circulation: metho... 324415 - Hypertonic mannitol in the therapy of the acute respiratory distress syndrome. 12781315 - Nasal cpap treatment for obstructive sleep apnea: developing a new perspective on dosin... |
Publication Detail:
|
Type: Journal Article Date: 2012-04-09 |
Journal Detail:
|
Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 14 ISSN: 1751-7176 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-04-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
|
Languages: eng Pagination: 293-8 Citation Subset: IM |
Copyright Information:
|
© 2012 Wiley Periodicals, Inc. |
Affiliation:
|
From the Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nuremberg, Erlangen;the Department of Nephrology and Hypertension, University of Erlangen-Nuremberg, Erlangen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Blood pressure-lowering efficacy of the fixed-dose combination of azilsartan medoxomil and chlorthal...
Next Document: Comparative Efficacy of Aliskiren/Valsartan vs Valsartan in Nocturnal Dipper and Nondipper Hypertens...