Document Detail


Effect of route and frequency of administration of apomorphine on growth hormone release in African catfish (Clarias gariepinus).
MedLine Citation:
PMID:  9150417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Apomorphine is known to stimulate growth hormone release in African catfish following an intraperitoneal (IP) injection. In the present study the effect of apomorphine (5 or 20 mg/kg body weight) on plasma GH levels was evaluated after gastro-intestinal or parenteral delivery. Apomorphine increased the plasma GH concentration regardless of the route of administration, indicating that apomorphine can be absorbed from the intestinal tract. The effect of repeated administration of apomorphine differed clearly between the tested doses. Although a single IP injection with 20 mg apomorphine/kg body weight resulted in a clear increase in plasma GH levels, a second injection given 12 hours later was ineffective. In contrast the last of 4 consecutive injections with 5 mg apomorphine/kg body weight given at intervals of 12 hours stimulated the plasma GH levels in a similar way to a single IP injection with the same dose.
Authors:
O Lescroart; I Roelants; N Cauwenberghs; R De Schrijver; E R Kühn; F Ollevier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  60     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1997  
Date Detail:
Created Date:  1997-06-03     Completed Date:  1997-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1771-9     Citation Subset:  IM    
Affiliation:
Laboratory of Ecology and Aquaculture, Zoological Institute, Catholic University of Leuven, Belgium. Olivier.Lescroart@bio.kuleuven.ac.be
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MeSH Terms
Descriptor/Qualifier:
Animals
Apomorphine / administration & dosage*
Catfishes
Dopamine Agonists / administration & dosage*
Drug Administration Routes
Drug Administration Schedule
Female
Growth Hormone / blood*,  secretion*
Injections, Intraperitoneal
Intubation, Gastrointestinal
Male
Rectum
Chemical
Reg. No./Substance:
0/Dopamine Agonists; 58-00-4/Apomorphine; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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