| Effect of rotavirus infection on lipid composition and glucose uptake in infant mouse intestine. | |
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MedLine Citation:
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PMID: 11206867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the effect of rotavirus infection on lipid composition and glucose uptake in small intestine of infant mice. METHODS: Thirty six 7-day old balb/c mice were given 50 mL (100 ID50) rotavirus suspension orally; 36 control animals received only normal saline. Body weight of animals was recorded. Six animals in each group were sacrificed on days 0, 1, 3, 5, 7 and 10 post-inoculation (pi). Intestines were removed, everted and homogenized in ice-cold saline. Cholesterol and phospholipid content, glucose uptake and alkaline phosphatase in the jejunum and ileum were determined. RESULTS: Rotavirus infection led to a significant decrease in body weight with on days 3 and 5 pi as compared to controls, and to an increase in cholesterol and phospholipid content of the intestine. Uptake of glucose also increased significantly. Alkaline phosphatase activity was significantly reduced on days 3 and 5 pi as compared to controls. CONCLUSION: This study provides characterization of the lipid composition and uptake of glucose in infant mice small intestinal segments during rotavirus infection. |
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Authors:
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R Katyal; S Rana; K Vaiphei; S Ojha; V Singh; K Singh |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology Volume: 20 ISSN: 0254-8860 ISO Abbreviation: Indian J Gastroenterol Publication Date: 2001 Jan-Feb |
Date Detail:
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Created Date: 2001-02-06 Completed Date: 2001-05-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8409436 Medline TA: Indian J Gastroenterol Country: India |
Other Details:
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Languages: eng Pagination: 18-21 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Disease Models, Animal Female Glucose / metabolism* Intestinal Absorption / physiology* Jejunum / metabolism*, virology Male Mice Mice, Inbred BALB C Phospholipids / metabolism* Probability Reference Values Rotavirus Infections / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Phospholipids; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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