| Effect of rotational atherectomy on the coronary microcirculation in patients with angina pectoris. | |
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MedLine Citation:
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PMID: 16127893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The coronary microcirculation can be impaired by ablated debris just after a rotational atherectomy procedure, but the specific effects of rotablation on the microcirculation have not been investigated. The present study examined the effects of rotational atherectomy on the coronary microcirculation by analyzing coronary flow reserve (CFR) and the component parameters of the coronary flow-pressure loop. METHODS: This study included 31 patients with angina pectoris who underwent stent implantation after rotational atherectomy and with < 50% diameter stenosis at 6-month follow-up (i.e. without clinical restenosis). The CFR, the flow-pressure slope index (FPSI) and zero-flow pressure were measured using the FloWire Doppler guidewire in both treated and untreated reference vessels without stenosis immediately after and on 6 months from the rotational atherectomy procedure. RESULTS: CFR and FPSI in the treated vessels were significantly lower than in the untreated reference vessels without stenosis just after rotational atherectomy (CFR: 2.1 +/- 0.5 vs 2.6 +/- 0.7, p < 0.05; FPSI: 1.61 +/- 0.8 vs 2.35 +/- 0.9 cm/sec/mmHg, p < 0.05), but no significant differences were observed in CFR or FPSI between these same sets of arteries at follow-up. There was also a significant correlation between the extent of attenuation of CFR and total ablation time (r = - 0.54, p < 0.01). CONCLUSIONS: Rotational atherectomy attenuates CFR by reducing coronary artery conductance, probably due to coronary microvessel obstruction with the debris ablated during the procedures of rotational atherectomy. |
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Authors:
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Takahiro Tanaka; Yutaka Shimizu; Akiko Ishihara; Kohei Yano; Toshikatsu Sada; Yuji Kira |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiology Volume: 46 ISSN: 0914-5087 ISO Abbreviation: J Cardiol Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-30 Completed Date: 2005-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: Japan |
Other Details:
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Languages: eng Pagination: 43-51 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Showa General Hospital, Tokyo. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / physiopathology*, surgery* Atherectomy, Coronary* Coronary Circulation / physiology* Female Humans Male Microcirculation / physiology* Stents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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