Document Detail


Effect of rosuvastatin on atrial structural remodeling in rabbits with myocardial infarction.
MedLine Citation:
PMID:  25469252     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The present study aimed to investigate the effect of rosuvastatin on atrial structural remodeling in rabbits with myocardial infarction (MI). The rabbits were randomly divided into 4 groups: The sham operation group (S; n=8), the MI group (MI; n=7), the group with low-dose rosuvastatin [Rs; 2.5 mg/(kg/d), n=7] and the group with high-dose rosuvastatin [Rl, 5 mg/(kg/d), n=8]. A rabbit MI model was established via ligation of the anterior descending coronary artery. After 8 weeks of intervention, the left atrial diameter (LAD), atrial collagen content, expression level of type I collagen and left ventricular ejection fraction (LVEF) were measured. LAD in the MI group was significantly larger than the S, Rs and Rl groups after 8 weeks. The left atrial collagen content of the MI group was also significantly greater than those observed in the other 3 groups. The expression of type I collagen in the MI group was significantly increased compared to the other 3 groups. However, LVEF of the MI group was lower compared to the other 3 groups. There were no significant differences between the Rs and Rl groups in the above indexes. In conclusion, rosuvastatin can improve post-MI atrial structural remodeling.
Authors:
Weijie Wang; Yujiao Zhang; Mei Gao; Jiangrong Wang; Yinglong Hou
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-26
Journal Detail:
Title:  Biomedical reports     Volume:  3     ISSN:  2049-9434     ISO Abbreviation:  Biomed Rep     Publication Date:  2015 Jan 
Date Detail:
Created Date:  2014-12-3     Completed Date:  -     Revised Date:  2014-12-4    
Medline Journal Info:
Nlm Unique ID:  101613227     Medline TA:  Biomed Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  78-82     Citation Subset:  -    
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