| Effect of rosiglitazone on rabbit model of myocardial ischemia-reperfusion injury. | |
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MedLine Citation:
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PMID: 23375039 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To explore mechanism and protective effect of rosiglitazone on myocardial ischemia reperfusion (I/R) injury. METHODS: A total of 48 male Japanese white big-ear rabbits were randomly divided into control group (A), I/R group (B), low dose of rosiglitazone group (C), high dose of rosiglitazone group (D). Plasma concentration of and also reduced the concentration of plasma serum creatine kinase (CK), CK-MB, high-sensitivity C-reactive protein (hsCRP), ultra-superoxide dismutase (SOD), malondialdehyde (MDA), lactic acid glutathione skin peroxidase (GSH-PX), nitric oxide (NO) and endothelin (ET) were measured 1 h later after I/R. Twenty-four hours after I/R the hearts were harvested for pathological and ultrastructural analysis. Area of myocardial infarction were tested. RESULTS: Plasma concentration of CK, CK-MB, hsCRP, NO, MDA and ET were decreased in C, D group compared with group B. Plasma concentration of T-SOD and GSH-Px were increased significantly in C, D group compared with group B. Compared with group B, pathological and ultrastructural changes in C and D group were slightly. There was significant difference in myocardial infarction area between group C, D and group B (P<0.05). Myocardial infarction area and arrhythmia rate were lower in group C, D compare with group B. CONCLUSIONS: Rosiglitazone may protect myocardium from I/R injury by enhancing T-SOD and GSH-Px concentration, inhibit inflammatory reaction, and improve endothelial function. |
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Authors:
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Xia-Qing Gao; Hua-Wei Li; Xue Ling; Ya-Hui Qiu; Yue Gao; Yang Zhang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Asian Pacific journal of tropical medicine Volume: 6 ISSN: 1995-7645 ISO Abbreviation: Asian Pac J Trop Med Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101533720 Medline TA: Asian Pac J Trop Med Country: Singapore |
Other Details:
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Languages: eng Pagination: 228-31 Citation Subset: IM |
Copyright Information:
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Copyright © 2013 Hainan Medical College. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Liaoning Medical University, Jinzhou 121000, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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