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Effect of rimonabant on oesophageal motor function in man.
MedLine Citation:
PMID:  21251031     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background  Cannabinoid type 1 (CB1) receptors are implicated in the control of transient lower oesophageal sphincter relaxations (TLESRs) in animals. In man, it is unclear whether CB1 receptors are involved in the control of oesophageal function. Aim  To study the effects of the CB1 receptor antagonist rimonabant on fasting and postprandial LES function in healthy subjects. Methods  Twelve healthy volunteers underwent two oesophageal manometry studies with administration of wet swallows and a meal after 3 days' premedication with placebo or rimonabant 20 mg. Results  Rimonabant did not significantly alter preprandial LES pressure (21.1 ± 4.0 vs. 17.3 ± 3.0 mmHg, N.S.), but postprandial LES pressures were significantly enhanced (9.9 ± 1.9 vs.17.1 ± 2.7 mmHg in the first and 10.0 ± 1.4 vs. 19.3 ± 3.6 mmHg in the second postprandial hour, both P < 0.05). Swallow-induced relaxations and amplitude of peristaltic contractions were not altered, but rimonabant significantly increased the duration of peristaltic contractions at all time points (e.g. 5.0 ± 0.3 vs. 8.0 ± 0.3 s preprandially and 5.0 ± 0.2 vs. 8.2 ± 0.3 s at 60 min postprandially, both P < 0.01). The number of postprandial TLESRs (3.1 ± 0.5 vs. 1.2 ± 0.5, P < 0.05) and acid reflux episodes (1.4 ± 0.2 vs. 0.3 ± 0.1, P < 0.05) were significantly lower after rimonabant. Conclusion  The CB1 receptor antagonist rimonabant enhances postprandial LES pressure and decreases TLESRs in healthy subjects.
Authors:
E Scarpellini; K Blondeau; V Boecxstaens; R Vos; A Gasbarrini; R Farré; J Tack
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-20
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  -     ISSN:  1365-2036     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium.
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