| Effect of right ventricular volume overload on left ventricular diastolic function in patients with atrial septal defect. | |
| | |
MedLine Citation:
|
PMID: 8933238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study was undertaken to investigate the effect of chronic right ventricular (RV) volume overload on left ventricular (LV) diastolic function. Twelve patients with atrial septal defect and 7 age-matched normal controls were examined. Patients with atrial septal defect were divided into 2 groups based on their Qp/Qs values (ASD1:Qp/Qs < or = 3, n = 7; ASD2:Qp/Qs > 3, n = 5). The LV volume curve and its first derivative were derived by a frame-by-frame analysis of the left ventriculogram. The peak filling rate was defined by the peak positive first derivative of the LV volume curve. We measured the time constant, isovolumetric relaxation time, stiffness constant and compliance at LV end-diastole. The time constant was significantly prolonged in the ASD2 group compared with the controls, and the isovolumetric relaxation time in both atrial septal defect groups was also prolonged compared with the controls. The peak filling rate, which was normalized by end-diastolic volume, was lower in the ASD2 group than in the controls. Although the stiffness constant and the compliance at LV end-diastole in the controls were not significantly different from those in the atrial septal defect group, an upward and leftward displacement of the left ventricular pressure-volume curve was observed in patients with atrial septal defect. Moreover, a significant correlation (r = 0.78, p < 0.01) was observed between the time constant and RV end-diastolic pressure. Thus, these results suggest that chronic RV volume overload affects left ventricular diastolic function. |
| | |
Authors:
|
A Satoh; K Katayama; T Hiro; M Yano; T Miura; M Kohno; T Fujii; M Matsuzaki |
Related Documents
:
|
9869498 - In vivo left ventricular function and collagen expression in aldosterone/salt-induced h... 15917708 - Myocardial compliance was not altered after acute induction of atrial fibrillation in s... 12633798 - Predictors of left ventricular reverse remodeling after cardiac resynchronization thera... 12220068 - A rat model of ischemic cardiomyopathy for investigating left ventricular volume reduct... 6351148 - Attention and autonomic self-regulation. 10712338 - Influence of body weight on the severity of dyspnea in chronic obstructive pulmonary di... |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Japanese circulation journal Volume: 60 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1996 Oct |
Date Detail:
|
Created Date: 1997-02-11 Completed Date: 1997-02-11 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 758-66 Citation Subset: IM |
Affiliation:
|
Second Department of Internal Medicine, Yamaguchi University, School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Bundle-Branch Block / physiopathology Cardiac Volume* Diastole Female Heart Septal Defects, Atrial / physiopathology* Hemodynamics Humans Male Matched-Pair Analysis Middle Aged Myocardial Contraction Ventricular Function, Left* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Identification of pseudonormal transmitral flow pattern using color Doppler echocardiography.
Next Document: Comparison of the therapeutic effects of the beta-blocking agent bisoprolol and the calcium-blocking...