Document Detail

Effect of right ventricular volume overload on left ventricular diastolic function in patients with atrial septal defect.
MedLine Citation:
PMID:  8933238     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to investigate the effect of chronic right ventricular (RV) volume overload on left ventricular (LV) diastolic function. Twelve patients with atrial septal defect and 7 age-matched normal controls were examined. Patients with atrial septal defect were divided into 2 groups based on their Qp/Qs values (ASD1:Qp/Qs < or = 3, n = 7; ASD2:Qp/Qs > 3, n = 5). The LV volume curve and its first derivative were derived by a frame-by-frame analysis of the left ventriculogram. The peak filling rate was defined by the peak positive first derivative of the LV volume curve. We measured the time constant, isovolumetric relaxation time, stiffness constant and compliance at LV end-diastole. The time constant was significantly prolonged in the ASD2 group compared with the controls, and the isovolumetric relaxation time in both atrial septal defect groups was also prolonged compared with the controls. The peak filling rate, which was normalized by end-diastolic volume, was lower in the ASD2 group than in the controls. Although the stiffness constant and the compliance at LV end-diastole in the controls were not significantly different from those in the atrial septal defect group, an upward and leftward displacement of the left ventricular pressure-volume curve was observed in patients with atrial septal defect. Moreover, a significant correlation (r = 0.78, p < 0.01) was observed between the time constant and RV end-diastolic pressure. Thus, these results suggest that chronic RV volume overload affects left ventricular diastolic function.
A Satoh; K Katayama; T Hiro; M Yano; T Miura; M Kohno; T Fujii; M Matsuzaki
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  60     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-02-11     Completed Date:  1997-02-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  758-66     Citation Subset:  IM    
Second Department of Internal Medicine, Yamaguchi University, School of Medicine, Japan.
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MeSH Terms
Bundle-Branch Block / physiopathology
Cardiac Volume*
Heart Septal Defects, Atrial / physiopathology*
Matched-Pair Analysis
Middle Aged
Myocardial Contraction
Ventricular Function, Left*

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