Document Detail

Effect of right ventricular function and pulmonary pressures on heart failure prognosis.
MedLine Citation:
PMID:  20377809     Owner:  NLM     Status:  MEDLINE    
The relationship of right ventricular function and pulmonary systolic pressure in patients with congestive heart failure was evaluated to risk-stratify them. The study included 147 consecutive patients with symptomatic heart failure who underwent clinical and laboratory examination and echocardiography including Doppler tissue echocardiography. They were followed for a mean of 11.2+/-6.4 months. During follow-up, 16 patients died and 45 patients had nonfatal cardiac events. There were 60 readmissions for heart failure. Pulmonary artery systolic pressure and right ventricular systolic function were inversely related (r(2)=0.66, P<.001). On Cox multivariate survival analysis, early worsening of pulmonary arterial pressures was an independent prognostic predictor (hazard ratio, 0.44; confidence interval, 0.28-0.91, P=.024). The patients with pulmonary hypertension and right ventricular systolic dysfunction had the worst prognosis. The assessments of right ventricular function help to risk-stratify patients with heart failure. The early worsening of pulmonary hypertension is a powerful predictor of worse prognosis.
Srilakshmi M Adhyapak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Preventive cardiology     Volume:  13     ISSN:  1751-7141     ISO Abbreviation:  Prev Cardiol     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-09     Completed Date:  2010-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9813731     Medline TA:  Prev Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  72-7     Citation Subset:  IM    
Department of Cardiology, St. John's Medical College Hospital, Bangalore, India.
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Confidence Intervals
Echocardiography, Doppler
Heart Failure / mortality*,  physiopathology*,  ultrasonography
Lung / physiopathology,  ultrasonography
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Pulmonary Artery / physiopathology*,  ultrasonography
Pulmonary Wedge Pressure*
ROC Curve
Risk Factors
Statistics as Topic
Stroke Volume
Survival Analysis
Ventricular Function, Right*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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