Document Detail

Effect of riboflavin or pyridoxine deficiency on inflammatory response.
MedLine Citation:
PMID:  1812086     Owner:  NLM     Status:  MEDLINE    
Inflammatory response has been assessed in riboflavin or pyridoxine deficient rats. Edema was increased by 54% in pyridoxine deficiency as compared to weight-matched control rats. Food restriction per se reduced the volume of edema by 63%. In pyridoxine deficiency, concentrations of thiobarbituric acid reactive substances (which indicate the extent of lipid peroxidation) increase by 30 and 43% respectively in the edematous tissues of the paw as well as in the wounded skin. Both these parameters were not affected by riboflavin deficiency. Activities of NADPH oxidase and superoxide dismutase in elicited leukocytes from peritoneal cavity were reduced by 54 and 52%, respectively, in riboflavin deficiency but were unaltered in pyridoxine deficiency. Superoxide level and acid phosphatase activity were not influenced by either of the deficiencies, whereas hydrogen peroxide level was increased by 48% in riboflavin deficiency. Food restriction did not affect leukocyte enzymes or the levels of reduced oxygen species. The data suggest that inflammation is enhanced in pyridoxine deficiency but not in riboflavin deficiency.
R Lakshmi; A V Lakshmi; P V Divan; M S Bamji
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of biochemistry & biophysics     Volume:  28     ISSN:  0301-1208     ISO Abbreviation:  Indian J. Biochem. Biophys.     Publication Date:    1991 Oct-Dec
Date Detail:
Created Date:  1992-06-09     Completed Date:  1992-06-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0310774     Medline TA:  Indian J Biochem Biophys     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  481-4     Citation Subset:  IM    
National Institute of Nutrition, Hyderabad, India.
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MeSH Terms
Inflammation / etiology*
Lipid Peroxides / metabolism
Rats, Inbred Strains
Riboflavin Deficiency / complications*,  metabolism
Vitamin B 6 Deficiency / complications*,  metabolism
Wound Healing
Reg. No./Substance:
0/Lipid Peroxides

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