Document Detail

Effect of rhodoxanthin from Potamogeton crispus L. on cell apoptosis in Hela cells.
MedLine Citation:
PMID:  16919415     Owner:  NLM     Status:  MEDLINE    
Carotenoid, a natural functional pigment, is known to have anti-carcinogenic activity. To verify the anti-cancer effects of rhodoxanthin which is a kind of carotenoids, we investigated the effects of rhodoxanthin from Potamogeton crispus L. on the proliferation rate, cell cycle distribution, apoptosis and the change in mitochondrial membrane potential in Hela cell line. The effects of rhodoxanthin were also tested on the concentration of Ca(2+) in cells. Rhodoxanthin inhibited cell proliferation in Hela cells in a dose and time-dependent manner. Rhodoxanthin induced an accumulation of cells in the S phase of the cell cycle, reduced the mitochondria transmembrane potential and increased the concentration of intracellular Ca(2+). In summary, our results suggested that rhodoxanthin-induced apoptosis in Hela cells occurred via these pathways.
Dandan Ren; Guanghua Peng; Hongxia Huang; Haibin Wang; Shenghua Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-12
Journal Detail:
Title:  Toxicology in vitro : an international journal published in association with BIBRA     Volume:  20     ISSN:  0887-2333     ISO Abbreviation:  Toxicol In Vitro     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-10-18     Completed Date:  2006-12-26     Revised Date:  2009-04-10    
Medline Journal Info:
Nlm Unique ID:  8712158     Medline TA:  Toxicol In Vitro     Country:  England    
Other Details:
Languages:  eng     Pagination:  1411-8     Citation Subset:  IM    
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China.
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MeSH Terms
Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis / drug effects*
Calcium / metabolism
Cell Cycle / drug effects
Cell Proliferation / drug effects
Coloring Agents
Flow Cytometry
Hela Cells
Membrane Potentials / drug effects
Mitochondrial Membranes / drug effects
Potamogetonaceae / chemistry*
Xanthophylls / pharmacology*
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Coloring Agents; 0/Xanthophylls; 116-30-3/rhodoxanthin; 36015-30-2/Propidium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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