| Effect of rhodoxanthin from Potamogeton crispus L. on cell apoptosis in Hela cells. | |
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MedLine Citation:
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PMID: 16919415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carotenoid, a natural functional pigment, is known to have anti-carcinogenic activity. To verify the anti-cancer effects of rhodoxanthin which is a kind of carotenoids, we investigated the effects of rhodoxanthin from Potamogeton crispus L. on the proliferation rate, cell cycle distribution, apoptosis and the change in mitochondrial membrane potential in Hela cell line. The effects of rhodoxanthin were also tested on the concentration of Ca(2+) in cells. Rhodoxanthin inhibited cell proliferation in Hela cells in a dose and time-dependent manner. Rhodoxanthin induced an accumulation of cells in the S phase of the cell cycle, reduced the mitochondria transmembrane potential and increased the concentration of intracellular Ca(2+). In summary, our results suggested that rhodoxanthin-induced apoptosis in Hela cells occurred via these pathways. |
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Authors:
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Dandan Ren; Guanghua Peng; Hongxia Huang; Haibin Wang; Shenghua Zhang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-07-12 |
Journal Detail:
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Title: Toxicology in vitro : an international journal published in association with BIBRA Volume: 20 ISSN: 0887-2333 ISO Abbreviation: Toxicol In Vitro Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-10-18 Completed Date: 2006-12-26 Revised Date: 2009-04-10 |
Medline Journal Info:
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Nlm Unique ID: 8712158 Medline TA: Toxicol In Vitro Country: England |
Other Details:
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Languages: eng Pagination: 1411-8 Citation Subset: IM |
Affiliation:
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College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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pharmacology* Apoptosis / drug effects* Calcium / metabolism Cell Cycle / drug effects Cell Proliferation / drug effects Coloring Agents Flow Cytometry Hela Cells Humans Membrane Potentials / drug effects Mitochondrial Membranes / drug effects Potamogetonaceae / chemistry* Propidium Xanthophylls / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Coloring Agents; 0/Xanthophylls; 116-30-3/rhodoxanthin; 36015-30-2/Propidium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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