Document Detail


Effect of return to overuse activity following an isolated supraspinatus tendon tear on adjacent intact tendons and glenoid cartilage in a rat model.
MedLine Citation:
PMID:  23280495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rotator cuff tears are common conditions that can alter shoulder mechanics and may lead to damage of intact joint tissues. These injuries are of particular concern in populations who perform tasks requiring repetitive overhead activity (e.g., athletes and laborers) and who are likely to return to aggressive pre-injury activity levels despite limited understanding of the potentially damaging effects on the remaining tissues. Therefore, we investigated the effect of returning to overuse activity following a supraspinatus tear on shoulder function and the mechanical properties of the remaining intact tendons and glenoid cartilage. Forty rats underwent 4 weeks of overuse activity to create a tendinopathic condition followed by detachment of the supraspinatus tendon and were then randomized into two groups: continued overuse or cage activity. Ambulatory measurements were performed throughout the 8 weeks prior to euthaniasia, and properties of the adjacent tendons and cartilage were evaluated. Results demonstrated that shoulder function was not compromised in the return to overuse group. However, alterations of the glenoid cartilage and biceps tendon properties occurred. Our results help define the contributory roles of common mechanical injury mechanisms and provide a framework by which physicians could better prescribe long-term treatment strategies for patients.
Authors:
Katherine E Reuther; Stephen J Thomas; Joseph J Sarver; Jennica J Tucker; Chang-Soo Lee; Chancellor F Gray; David L Glaser; Louis J Soslowsky
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-12-31
Journal Detail:
Title:  Journal of orthopaedic research : official publication of the Orthopaedic Research Society     Volume:  31     ISSN:  1554-527X     ISO Abbreviation:  J. Orthop. Res.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-05-07     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  8404726     Medline TA:  J Orthop Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  710-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Orthopaedic Research Society.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanical Phenomena / physiology
Cumulative Trauma Disorders / physiopathology*
Disease Models, Animal
Elasticity / physiology
Glenoid Cavity / physiopathology*
Male
Muscle, Skeletal / physiology
Rats
Rats, Sprague-Dawley
Rotator Cuff / injuries*,  physiopathology*
Running / physiology
Shoulder Joint / physiopathology*
Tendon Injuries / physiopathology*
Grant Support
ID/Acronym/Agency:
P30 AR050950/AR/NIAMS NIH HHS; R01 AR056658/AR/NIAMS NIH HHS; R01AR056658/AR/NIAMS NIH HHS; T32 AR007132/AR/NIAMS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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