Document Detail


Effect of retinoic acid on hemolymph glucose regulation in the fresh water edible crab Oziotelphusa senex senex.
MedLine Citation:
PMID:  17964575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
9-cis-Retinoic acid (9CRA) and all-trans-retinoic acid (ATRA) are known to be involved in the regulation of glucose homeostasis in vertebrates by inducing insulin release and expression of glucose reporter proteins. In view of the fact that 9CRA and ATRA are endogenous in crustaceans and a retinoic acid X-receptor exists in crabs, we investigated whether 9CRA and ATRA also plays a role in glucose homeostasis in freshwater crab, Oziotelphusa senex senex. Injection of 9CRA into intact crabs significantly increased the hemolymph glucose level in a dose-dependent manner. Such 9CRA-induced hyperglycemia was apparently mediated by the CHH since injection of 9CRA into eyestalk-ablated crabs did not result in hyperglycemia. In support of this, administration of 9CRA in to crabs resulted in reduced hyperglycemic activity of eyestalks and elevated titers of CHH in hemolymph. ATRA injection did not cause any changes in hemolymph glucose and CHH levels. The results provide the first evidence that 9-cis-retinoic acid, but not all-trans-retinoic acid, is involved in the regulation of glucose homeostasis and apparently mediated by the eyestalk hormone CHH.
Authors:
P Sreenivasula Reddy; S B Sainath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-26
Journal Detail:
Title:  General and comparative endocrinology     Volume:  155     ISSN:  0016-6480     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-11     Completed Date:  2008-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  496-502     Citation Subset:  IM    
Affiliation:
Department of Biotechnology, Sri Venkateswara University, Tirupati 517502, India. reddy_1955@yahoo.co.in
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism*
Brachyura / drug effects,  metabolism*
Endocrine Glands / chemistry,  metabolism
Eye / chemistry,  metabolism
Fresh Water
Hemolymph / chemistry,  metabolism*
Hyperglycemia / chemically induced
Male
Nerve Tissue Proteins / chemistry,  pharmacology
Tissue Extracts / pharmacology
Tretinoin / pharmacology*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Nerve Tissue Proteins; 0/Tissue Extracts; 0/hyperglycemic hormone, crustacean; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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