Document Detail

Effect of retinoic acid, butylated hydroxytoluene, propylgallate and selenium on 2-acetylaminofluorene induced hepatotoxicity.
MedLine Citation:
PMID:  4075287     Owner:  NLM     Status:  MEDLINE    
Rats of the Sprague-Dawley strain were administered 2-acetylaminofluorene (2-AAF) in different diet regimens to ascertain the effect of retinoic acid(RA), butylated hydroxytoluene (BHT), propylgallate (PG), and selenium on induced hepatotoxicity. In the first study, groups of young male albino rats of the Sprague-Dawley strain were fed a diet containing 0.05% 2-AAF. Carcinogen was added to the diet for 3 weeks, omitted 1 week, added 2 weeks, omitted 2 weeks, added 3 weeks, and omitted for the final 4 weeks. Animals were terminated at the end of 15 weeks. Supplementation of the diet by 0.5% BHT, PG or 4 ppm selenium as sodium selenite in the drinking water either throughout the entire feeding period or only during the administration of the carcinogen-free diet greatly inhibited the hepatotoxicity of 2-AAF. In contrast, addition of 0.02% RA to the diet in the above feeding regimens enhanced the hepatotoxicity of 2-AAF. In the second study, male and female Sprague-Dawley rats were administered a diet containing 0.03% 2-AAF for 16 weeks or a diet containing 0.03% 2-AAF supplemented with 0.02% RA for the first 4 weeks and the last 6 weeks of the 16-week feeding period. Addition of the 0.02% RA to the diet enhanced the hepatotoxicity of 2-AAF, especially in the female rats.
A H Daoud; A C Griffin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  29     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1986-01-29     Completed Date:  1986-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  183-8     Citation Subset:  IM    
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MeSH Terms
2-Acetylaminofluorene / toxicity*
Body Weight / drug effects
Butylated Hydroxytoluene / pharmacology*
Drug Interactions
Gallic Acid / analogs & derivatives*
Liver / drug effects*
Propyl Gallate / pharmacology*
Rats, Inbred Strains
Selenium / pharmacology*
Sex Factors
Time Factors
Tretinoin / pharmacology*
Reg. No./Substance:
121-79-9/Propyl Gallate; 128-37-0/Butylated Hydroxytoluene; 149-91-7/Gallic Acid; 302-79-4/Tretinoin; 53-96-3/2-Acetylaminofluorene; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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