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Effect of resveratrol on the fundus oculi : An overview.
MedLine Citation:
PMID:  23354354     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Resveratrol is a polyphenol with various properties. Oncological studies have shown an excellent anti-carcinogenic effect. Due to many overlaps between tumor-mediating signaling pathways and those which mediate neovascularization and proliferation in retinal diseases, this review intends to focus on studies about the application of resveratrol in diseases of the eye fundus in vitro and in vivo. Resveratrol has been well investigated in cell culture studies and animal models. Ophthalmological in vitro and in vivo investigations have shown a large variety of possible effects without toxic side effects and antiproliferative and immune modulatory effects in particular were observed. There is general consensus that the target protein of resveratrol is NF-κB. Clinical studies are needed to confirm these effects observed in cell culture and animal models. The exact mechanism of resveratrol remains unknown and seems to vary between cell types, tissues and the pathophysiological environment.
Authors:
A F Alex; N Eter
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-27
Journal Detail:
Title:  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft     Volume:  -     ISSN:  1433-0423     ISO Abbreviation:  Ophthalmologe     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206148     Medline TA:  Ophthalmologe     Country:  -    
Other Details:
Languages:  GER     Pagination:  -     Citation Subset:  -    
Affiliation:
Universitäts-Augenklinik Münster, Albert-Schweitzer-Campus 1, Gebäude D15 , 48149, Münster, Deutschland, anne.alex@ukmuenster.de.
Vernacular Title:
Effekte von Resveratrol am Augenhintergrund : Ein Überblick.
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