Document Detail


Effect of resveratrol on endothelial cell function: Molecular mechanisms.
MedLine Citation:
PMID:  20730905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The polyphenolic natural product resveratrol (RV), best known for its occurrence in grape skin and red wine, is considered a candidate drug for prevention and treatment of cardiovascular diseases. This review aims to summarize the molecular effects of RV on endothelial cells, which line the inner walls of blood vessels and play a key role in the development of those diseases. We describe how RV enhances endothelial nitric oxide production, improves endothelial redox balance and inhibits endothelial activation in response to pro-inflammatory and metabolic insults. Furthermore, we summarize effects of RV on endothelial senescence, apoptosis, endothelin-1 release, and endothelial progenitor cell function. As many of RV's actions seem to be mediated by SIRT₁, different mechanistic possibilities how RV may lead to SIRT₁ activation are discussed.
Authors:
Christoph A Schmitt; Elke H Heiss; Verena M Dirsch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  36     ISSN:  1872-8081     ISO Abbreviation:  Biofactors     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-02-11     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  342-9     Citation Subset:  IM    
Copyright Information:
© 2010 International Union of Biochemistry and Molecular Biology, Inc.
Affiliation:
Wolfson Institute for Biomedical Research, University College London, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects
Cell Aging / drug effects
Endothelial Cells / drug effects*,  physiology*
Endothelin-1 / secretion
Humans
Inflammation / drug therapy
Nitric Oxide / biosynthesis
Nitric Oxide Synthase Type III / metabolism
Sirtuin 1 / drug effects
Stem Cells / physiology
Stilbenes / pharmacology*
Grant Support
ID/Acronym/Agency:
P 18982-B17//Austrian Science Fund FWF
Chemical
Reg. No./Substance:
0/Endothelin-1; 0/Stilbenes; 10102-43-9/Nitric Oxide; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 3.5.1.-/SIRT1 protein, human; EC 3.5.1.-/Sirtuin 1; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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