Document Detail

Effect of resuscitative mild hypothermia and oxygen concentration on the survival time during lethal uncontrolled haemorrhagic shock in mechanically ventilated rats.
MedLine Citation:
PMID:  15249808     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the hypothesis that resuscitative mild hypothermia (MH) (34 degrees C) or breathing fractional inspired oxygen (FIo2) of 1.0 would prolong survival time during lethal uncontrolled haemorrhagic shock (UHS) in mechanically ventilated rats. METHODS: Forty Wistar rats were anaesthetized with halothane, nitrous oxide and oxygen (70/30%), intubated and mechanically ventilated. UHS was induced by volume-controlled blood withdrawal of 3 ml/100 g over 15 min, followed by 75% tail amputation of its length. The animals were randomly divided into four UHS treatment groups (10 rats in each group): group 1 was maintained on an FIo2 of 0.21 and rectal temperature of 37.5 degrees C. Group 2 was maintained on an FIo2 of 0.21 and induced MH. Group 3 was maintained on an FIo2 of 1.0 and 37.5 degrees C. Group 4 was maintained on an FIo2 of 1.0 and MH. Rats were observed otherwise untreated until death. RESULTS: During the initial blood withdrawal, mean arterial pressure (MAP) decreased to 40 mmHg, and the heart rate (HR) increased up to 400 beats/min. The induction of MH increased MAP to 60 mmHg and increased survival time. Moreover, it reduced the HR to 300 beats/min but did not increase bleeding. Ventilation with an FIo2 of 1.0 did not influence MAP, blood loss or survival time, but increased arterial oxygen tension. The mean survival time was 62, 202, 68 and 209 min in groups 1, 2, 3 and 4, respectively. Blood loss from the tail was 1.0, 1.2, 0.9 and 0.7 ml, respectively, in groups 1, 2, 3 and 4. CONCLUSION: MH prolonged the survival time during UHS in mechanically ventilated rats. However, an FIo2 of 1.0 did not influence the survival time or blood loss from the tail.
Xin Yang; Said Hachimi-Idrissi; Duc Nam Nguyen; Martin Zizi; Luc Huyghens
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of emergency medicine : official journal of the European Society for Emergency Medicine     Volume:  11     ISSN:  0969-9546     ISO Abbreviation:  Eur J Emerg Med     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-13     Completed Date:  2004-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442482     Medline TA:  Eur J Emerg Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  210-6     Citation Subset:  IM    
Department of Critical Care Medicine and Cerebral Resuscitation Research Group, AZ-VUB, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
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MeSH Terms
Hypothermia, Induced*
Intubation, Intratracheal
Models, Animal
Oxygen / metabolism*
Oxygen Inhalation Therapy*
Rats, Wistar
Respiration, Artificial*
Resuscitation / methods*
Shock, Hemorrhagic / physiopathology,  therapy*
Survival Analysis
Time Factors
Reg. No./Substance:

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