Document Detail

Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women.
MedLine Citation:
PMID:  19683543     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to examine the acute effect of resistance exercise (RE) on muscle androgen receptor (AR) and glucocorticoid receptor (GR) protein content. Fifteen resistance-trained men (n=8; 21+/-1 years, 175.3+/-6.7 cm, 90.8+/-11.6 kg) and women (n=7; 24+/-5 years, 164.6+/-6.7 cm, 76.4+/-15.6 kg) completed 6 sets of 10 repetitions of heavy squats. Blood samples were obtained before RE, after 3 and 6 sets of squats, and 5, 15, 30 and 70 min after RE. Muscle biopsies from the vastus lateralis were obtained before RE, and 10 min and 70 min after RE. Blood samples were analyzed for total and free testosterone concentrations and muscle samples were analyzed for AR and GR protein content. Circulating total testosterone increased significantly (p< or =0.05) in men and free testosterone increased in men and women with exercise. AR was significantly reduced at 70 min post-exercise in men and at 10 min post-exercise in women compared to pre-exercise. There were no changes in GR following RE, but GR was significantly higher in women compared to men. These findings support a current paradigm for stabilization followed by a reduction and then a rebound in the acute AR response to RE but demonstrate that gender differences exist in the timeline of the AR response.
Jakob L Vingren; William J Kraemer; Disa L Hatfield; Jeff S Volek; Nicholas A Ratamess; Jeffrey M Anderson; Keijo H?kkinen; Juha Ahtiainen; Maren S Fragala; Gwendolyn A Thomas; Jen-Yu Ho; Carl M Maresh
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article     Date:  2009-08-14
Journal Detail:
Title:  Steroids     Volume:  74     ISSN:  1878-5867     ISO Abbreviation:  Steroids     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-10-28     Completed Date:  2010-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1033-9     Citation Subset:  IM    
Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA.
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MeSH Terms
Muscle, Skeletal / cytology,  metabolism*
Receptors, Androgen / metabolism*
Receptors, Glucocorticoid / metabolism*
Resistance Training*
Sex Factors
Testosterone / blood*
Young Adult
Reg. No./Substance:
0/Receptors, Androgen; 0/Receptors, Glucocorticoid; 58-22-0/Testosterone

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