Document Detail


Effect of reserpine pretreatment on stimulation of the accelerans nerve of the dog.
MedLine Citation:
PMID:  13592275     Owner:  NLM     Status:  OLDMEDLINE    
Abstract/OtherAbstract:
Pretreatment with two doses of reserpine (each 0.1 mg/kg, intraperitoneally) sensitizes the heart to the positive chronotropic action of norepinephrine and reduces the response to stimulation of the accelerans nerve. Ganglionic transmission remains unaffected. The results indicate that the presence of certain stores of peripheral sympathetic transmitter is essential for the production of tachycardia by stimulation of the accelerans nerve.
Authors:
U TRENDELENBURG; J S GRAVENSTEIN
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  128     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1958 Oct 
Date Detail:
Created Date:  1959-12-01     Completed Date:  2000-07-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  901-3     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Congenital Abnormalities / drug effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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