| Effect of reproterol either alone or combined with disodium cromoglycate on airway responsiveness to methacholine. | |
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MedLine Citation:
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PMID: 15939309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regular use of inhaled beta2-agonists might lead to tolerance as reflected in a loss of bronchoprotection. In vitro-data suggest that this might be prevented by disodium cromoglycate (DSCG). Therefore, we studied the effect of the beta2-agonist reproterol in combination with DSCG. In a cross-over design, 19 subjects with airway hyperresponsiveness inhaled either placebo, 1mg reproterol, 2 mg DSCG, or 1mg reproterol plus 2 mg DSCG 4x daily over 2 weeks. Treatment periods were separated by > or = 7 days. Before and at the end of periods, lung function and methacholine responsiveness were determined in the morning, and 6h later the bronchodilator effect and the protection against methacholine-induced bronchoconstriction. Reproterol or DSCG or their combination did not exert detrimental effects on lung function, airway responsiveness, or bronchodilator capacity. However, bronchoprotection was significantly reduced (p < 0.05) after treatment with placebo, reproterol or reproterol plus DSCG, the respective changes being 0.59, 0.96 and 1.37 doubling concentrations. All changes were small as compared to intraindividual variability. In this model all treatments except with DSCG caused a significant but small loss of protection against methacholine-induced bronchoconstriction. Thus, tolerance was not prevented by 2 weeks of additional treatment with DSCG, in contrast to in vitro findings. |
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Authors:
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Frank Kanniess; Rudolf A Jörres; Helgo Magnussen |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial Date: 2005-04-25 |
Journal Detail:
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Title: Pulmonary pharmacology & therapeutics Volume: 18 ISSN: 1094-5539 ISO Abbreviation: Pulm Pharmacol Ther Publication Date: 2005 |
Date Detail:
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Created Date: 2005-06-07 Completed Date: 2005-09-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9715279 Medline TA: Pulm Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 315-20 Citation Subset: IM |
Affiliation:
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Pulmonary Research Institute Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, D-22927 Grosshansdorf, Germany. f.kanniess@pulmoresearch.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adolescent Adult Bronchial Hyperreactivity / chemically induced, prevention & control* Bronchial Provocation Tests Bronchoconstrictor Agents / diagnostic use* Bronchodilator Agents / administration & dosage, pharmacology, therapeutic use* Cromolyn Sodium / administration & dosage, pharmacology, therapeutic use* Cross-Over Studies Double-Blind Method Drug Combinations Drug Therapy, Combination Female Humans Male Methacholine Chloride / diagnostic use* Middle Aged Orciprenaline / administration & dosage, analogs & derivatives*, pharmacology, therapeutic use Theophylline / administration & dosage, analogs & derivatives*, pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Bronchoconstrictor Agents; 0/Bronchodilator Agents; 0/Drug Combinations; 15826-37-6/Cromolyn Sodium; 54063-54-6/reproterol; 58-55-9/Theophylline; 586-06-1/Orciprenaline; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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