Document Detail

Effect of reproterol either alone or combined with disodium cromoglycate on airway responsiveness to methacholine.
MedLine Citation:
PMID:  15939309     Owner:  NLM     Status:  MEDLINE    
Regular use of inhaled beta2-agonists might lead to tolerance as reflected in a loss of bronchoprotection. In vitro-data suggest that this might be prevented by disodium cromoglycate (DSCG). Therefore, we studied the effect of the beta2-agonist reproterol in combination with DSCG. In a cross-over design, 19 subjects with airway hyperresponsiveness inhaled either placebo, 1mg reproterol, 2 mg DSCG, or 1mg reproterol plus 2 mg DSCG 4x daily over 2 weeks. Treatment periods were separated by > or = 7 days. Before and at the end of periods, lung function and methacholine responsiveness were determined in the morning, and 6h later the bronchodilator effect and the protection against methacholine-induced bronchoconstriction. Reproterol or DSCG or their combination did not exert detrimental effects on lung function, airway responsiveness, or bronchodilator capacity. However, bronchoprotection was significantly reduced (p < 0.05) after treatment with placebo, reproterol or reproterol plus DSCG, the respective changes being 0.59, 0.96 and 1.37 doubling concentrations. All changes were small as compared to intraindividual variability. In this model all treatments except with DSCG caused a significant but small loss of protection against methacholine-induced bronchoconstriction. Thus, tolerance was not prevented by 2 weeks of additional treatment with DSCG, in contrast to in vitro findings.
Frank Kanniess; Rudolf A Jörres; Helgo Magnussen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial     Date:  2005-04-25
Journal Detail:
Title:  Pulmonary pharmacology & therapeutics     Volume:  18     ISSN:  1094-5539     ISO Abbreviation:  Pulm Pharmacol Ther     Publication Date:  2005  
Date Detail:
Created Date:  2005-06-07     Completed Date:  2005-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9715279     Medline TA:  Pulm Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  315-20     Citation Subset:  IM    
Pulmonary Research Institute Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, D-22927 Grosshansdorf, Germany.
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MeSH Terms
Administration, Inhalation
Bronchial Hyperreactivity / chemically induced,  prevention & control*
Bronchial Provocation Tests
Bronchoconstrictor Agents / diagnostic use*
Bronchodilator Agents / administration & dosage,  pharmacology,  therapeutic use*
Cromolyn Sodium / administration & dosage,  pharmacology,  therapeutic use*
Cross-Over Studies
Double-Blind Method
Drug Combinations
Drug Therapy, Combination
Methacholine Chloride / diagnostic use*
Middle Aged
Orciprenaline / administration & dosage,  analogs & derivatives*,  pharmacology,  therapeutic use
Theophylline / administration & dosage,  analogs & derivatives*,  pharmacology,  therapeutic use
Reg. No./Substance:
0/Bronchoconstrictor Agents; 0/Bronchodilator Agents; 0/Drug Combinations; 15826-37-6/Cromolyn Sodium; 54063-54-6/reproterol; 58-55-9/Theophylline; 586-06-1/Orciprenaline; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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