Document Detail

Effect of reperfusion therapy on index of myocardial performance in acute myocardial infarction: thrombolytics versus primary angioplasty.
MedLine Citation:
PMID:  20339968     Owner:  NLM     Status:  MEDLINE    
It is known that primary angioplasty is more effective than thrombolytic therapy for the treatment of ST-segment elevation acute myocardial infarction. The aim of the present study is to compare the effects of the two strategies on the left ventricular functions using the Tei index (a combined myocardial performance index). Of 81 patients (11 female, mean age 52.7 +/- 11.9 years, and 70 male, mean age 54.8 +/- 11.5 years) matching the selection criteria, 41 patients were treated by primary percutaneous transluminal coronary angioplasty and stenting (group A, 41 patients) and 40 patients were treated by thrombolytic agents (streptokinase) (group B, 40 patients). All patients underwent a complete two-dimensional transthoracic echocardiographic and Doppler study in the left lateral decubitus position from multiple windows. There was no significant difference between the two groups in isovolumetric contraction time and ejection time. Isovolumetric relaxation time was 95.2 +/- 18.4 in group A and 116.2 +/- 28.1 in group B (P = 0.001) and the Tei index was 0.51 +/- 0.12 in group A and 0.59 +/- 0.16 in group B (P = 0.019). Isovolumetric relaxation time and Tei index were significantly higher in group B. Primary angioplasty is superior to thrombolytic therapy as assessed by the Tei index even in the first 3 h, with no apparent change in systolic function.
Ramazan Akdemir; Ozlem Karakurt; Harun Kilic; Asuman B Yesilay; Mehmet Dogan; Goksel Cagirci; Sadik Acikel; Nermin Akdemir
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Publication Detail:
Type:  Journal Article     Date:  2010-03-26
Journal Detail:
Title:  Heart and vessels     Volume:  25     ISSN:  1615-2573     ISO Abbreviation:  Heart Vessels     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  IM    
Department of Cardiology, Diskapi Yildirim Beyazit Research and Education Hospital, Ankara, Turkey.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary* / instrumentation
Echocardiography, Doppler
Fibrinolytic Agents / administration & dosage*
Middle Aged
Myocardial Contraction / drug effects
Myocardial Infarction / pathology,  physiopathology,  therapy*,  ultrasonography
Myocardium / pathology
Patient Selection
Prospective Studies
Streptokinase / administration & dosage*
Stroke Volume / drug effects
Thrombolytic Therapy*
Time Factors
Treatment Outcome
Ventricular Function, Left / drug effects*
Reg. No./Substance:
0/Fibrinolytic Agents; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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