Document Detail


Effect of reperfusion on left ventricular regional remodeling strains after myocardial infarction.
MedLine Citation:
PMID:  17954057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Reperfusion therapy for myocardial infarction is currently the most effective means for limiting early and late mortality. We sought to elucidate how reperfusion influences remodeling strains in the infarct, borderzone, and remote myocardial regions. Understanding the effects of reperfusion on regional remodeling will help to evaluate and optimize emerging treatments for patients who do not achieve effective reperfusion after myocardial infarction.
METHODS: An ovine infarct model (n = 13) was used to assess the effect of 1 hour of ischemia followed by reperfusion on regional and global myocardial geometry, function, and perfusion using sonomicrometry, echocardiography, and microspheres. Thirteen additional animals were assessed chronically (8 weeks) with echocardiography and postmortem analysis after either reperfusion (n = 5) or untreated infarction (n = 8).
RESULTS: During ischemia the area at risk thinned, stretched, and became dyskinetic. The normally perfused borderzone also stretched, and contraction decreased by 40% during ischemia. Reperfusion increased area at risk wall thickness and reduced area at risk stretching but did not restore contractile function. Borderzone stretching was reduced and contractile function improved by reperfusion. Contractile function of remote regions was also improved with reperfusion. Ventricular dilatation after ischemia was reversed within 180 minutes of reperfusion. Chronically, reperfusion significantly improved global remodeling when compared with nonreperfused controls. Reperfused animals had thicker infarcts and akinetic rather than dyskinetic apical segments.
CONCLUSIONS: Reperfusion acutely increases area at risk wall thickness, reduces area at risk and borderzone stretching, and improves borderzone and remote function. Reperfusion increases mature scar thickness and improves chronic global remodeling. These beneficial effects of reperfusion result primarily from reduced infarct expansion (stretching).
Authors:
Hiroaki Sakamoto; Landi M Parish; Hirotsugu Hamamoto; Liam P Ryan; Thomas J Eperjesi; Theodore J Plappert; Benjamin M Jackson; Martin G St John-Sutton; Joseph H Gorman; Robert C Gorman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  84     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-23     Completed Date:  2007-11-08     Revised Date:  2013-09-06    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1528-36     Citation Subset:  AIM; IM    
Affiliation:
Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Circulation
Echocardiography
Myocardial Infarction / pathology,  physiopathology,  therapy*
Myocardial Reperfusion*
Myocardium / pathology
Sheep
Stress, Mechanical
Systole
Ventricular Function, Left
Ventricular Remodeling*
Grant Support
ID/Acronym/Agency:
HL63954/HL/NHLBI NIH HHS; HL71137/HL/NHLBI NIH HHS; HL76560/HL/NHLBI NIH HHS; R01 HL063954/HL/NHLBI NIH HHS; R01 HL071137/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Ann Thorac Surg. 2007 Nov;84(5):1536-7   [PMID:  17954058 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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