Document Detail

Effect of repeated treatment with antidepressant drugs and electroconvulsive shock (ECS) on [3H] prazosin binding to different rat brain structures.
MedLine Citation:
PMID:  2830364     Owner:  NLM     Status:  MEDLINE    
The influence of acute and repeated treatment with imipramine, amitriptyline, mianserin, citalopram and ECS on alpha 1-adrenoceptors in different structures of the rat brain (cerebral cortex, hippocampus and thalamus) was measured using [3H] prazosin as a ligand. Repeated, but not acute, treatment with all the above antidepressant drugs and ECS induced an increase in the density of alpha 1-adrenoceptors in the cerebral cortex. On the other hand, no changes were found in the hippocampus and thalamus, with an exception of the increased number of [3H] prazosin binding sites in the thalamus after imipramine. The results suggest that the up-regulation of alpha 1-adrenoceptors following repeated antidepressant treatment is not a general phenomenon within the central nervous system.
G Nowak; E Przegaliński
Related Documents :
22559734 - Effects of 2-azafluorenones on phosphatidyl-inositol specific phospholipase c activatio...
2960424 - Hypothalamic alpha-melanocyte-stimulating hormone (alpha-msh) is not under dopaminergic...
2862264 - Peripheral cardiovascular alpha- and beta-adrenergic effects of some hypotensive and br...
2085714 - Endotoxin-induced impairment of vasopressor and vasodepressor responses in the pithed rat.
24189394 - Chitooligosaccharides suppress the freeze-denaturation of actomyosin in aristichthys no...
19722804 - Venodilatory effect of vascular endothelial growth factor on rat gingiva.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission     Volume:  71     ISSN:  -     ISO Abbreviation:  J. Neural Transm.     Publication Date:  1988  
Date Detail:
Created Date:  1988-03-28     Completed Date:  1988-03-28     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0337042     Medline TA:  J Neural Transm     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  57-64     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antidepressive Agents / administration & dosage*,  pharmacology
Brain / drug effects,  metabolism*,  physiopathology
Cerebral Cortex / drug effects,  metabolism,  physiopathology
Prazosin / metabolism*
Rats, Inbred Strains
Receptors, Adrenergic, alpha / metabolism*
Thalamus / drug effects,  metabolism,  physiopathology
Time Factors
Reg. No./Substance:
0/Antidepressive Agents; 0/Receptors, Adrenergic, alpha; XM03YJ541D/Prazosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Stress increases endogenous benzodiazepine receptor ligand-monoamine oxidase inhibitory activity (tr...
Next Document:  The effect of chronic lithium administration and withdrawal on locomotor activity and apomorphine-in...