Document Detail


Effect of repeated treatment with antidepressant drugs and electroconvulsive shock (ECS) on [3H] prazosin binding to different rat brain structures.
MedLine Citation:
PMID:  2830364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of acute and repeated treatment with imipramine, amitriptyline, mianserin, citalopram and ECS on alpha 1-adrenoceptors in different structures of the rat brain (cerebral cortex, hippocampus and thalamus) was measured using [3H] prazosin as a ligand. Repeated, but not acute, treatment with all the above antidepressant drugs and ECS induced an increase in the density of alpha 1-adrenoceptors in the cerebral cortex. On the other hand, no changes were found in the hippocampus and thalamus, with an exception of the increased number of [3H] prazosin binding sites in the thalamus after imipramine. The results suggest that the up-regulation of alpha 1-adrenoceptors following repeated antidepressant treatment is not a general phenomenon within the central nervous system.
Authors:
G Nowak; E Przegaliński
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission     Volume:  71     ISSN:  -     ISO Abbreviation:  J. Neural Transm.     Publication Date:  1988  
Date Detail:
Created Date:  1988-03-28     Completed Date:  1988-03-28     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0337042     Medline TA:  J Neural Transm     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  57-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antidepressive Agents / administration & dosage*,  pharmacology
Brain / drug effects,  metabolism*,  physiopathology
Cerebral Cortex / drug effects,  metabolism,  physiopathology
Electroshock*
Male
Prazosin / metabolism*
Rats
Rats, Inbred Strains
Receptors, Adrenergic, alpha / metabolism*
Thalamus / drug effects,  metabolism,  physiopathology
Time Factors
Chemical
Reg. No./Substance:
0/Antidepressive Agents; 0/Receptors, Adrenergic, alpha; XM03YJ541D/Prazosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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