Document Detail


Effect of repeated doses of dexamethasone on the incidence and severity of respiratory distress syndrome in multifetal gestation between 24 and 34 weeks.
MedLine Citation:
PMID:  11549860     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of the study was to evaluate the effects of antenatal corticosteroid therapy in multiple pregnancy on the incidence and severity of respiratory distress syndrome (RDS). Twenty-two women with twin, 12 with triplet and 2 with quadruplet pregnancies and an emergency group of 20 mothers with twin pregnancies, who only had one course of dexamethasone, were compared with controls. Corticosteroid therapy was associated with a reduction in moderate to severe RDS in all groups (twins p < 0.01, triplets and quadruplets p < 0.008) and the emergency group with dexamethasone therapy (p < 0.036) when compared to their individual controls. Dexamethasone reduced the duration of stay in the neonatal intensive care unit of the emergency twin group (p < 0.01). Neonatal birth weights were significantly less in all groups treated with repeated doses in comparison to the controls.
Authors:
M K Al-Yatama; M Al Essa; A E Omu; I Al-Shamali; P Egbase; N Rashwan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  52     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2001  
Date Detail:
Created Date:  2001-09-10     Completed Date:  2001-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  26-33     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Affiliation:
Department of Obstetrics and Gynecology, Faculty of Medicine, Kuwait University, Safat, Kuwait. sobha@hsc.kuniv.edu.kw
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / administration & dosage*
Dexamethasone / administration & dosage*
Female
Humans
Infant, Newborn
Kuwait
Pregnancy
Pregnancy, Multiple / drug effects*
Respiratory Distress Syndrome, Newborn / drug therapy*
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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