Document Detail

Effect of repeated administration of prolactin releasing peptide on feeding behavior in rats.
MedLine Citation:
PMID:  12419538     Owner:  NLM     Status:  MEDLINE    
Prolactin releasing peptide (PrRP) has been reported to reduce food intake in rats. We tested the effect of i.c.v. administration of PrRP-31 on food intake in both food deprived and free-feeding rats. We did not find any effect of PrRP-31 on food intake after single injections of up to an 8-nmol dose, but observed a marked decrease in food intake and body weight in rats that received a repeated twice daily administration of 8 nmol of PrRP-31. This effect was associated with an adverse behavioral pattern, indicating that the repeated high doses of the peptide caused non-specific effects inducing anorexia. We also tested several other behavioral parameters like locomotion and exploratory time, grooming and resting time, using lower doses of PrRP that did not cause the adverse behavior. Moreover, we carried out locomotor and sensory motor activity tests at the doses that exerted the most pronounced effect on the food intake. None of these tests suggested any specific behavioral effect of PrRP. We conclude that the behavioral pattern induced by PrRP is likely to be different from those induced by many other neuropeptides affecting food intake in rats.
Anna Valeria Vergoni; Hajime Watanobe; Giorgia Guidetti; Gustavo Savino; Alfio Bertolini; Helgi B Schiöth
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  955     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-06     Completed Date:  2003-01-31     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  207-13     Citation Subset:  IM    
Department of Biomedical Sciences, University of Modena, Modena, Italy.
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MeSH Terms
Eating / drug effects,  physiology
Feeding Behavior / drug effects*,  physiology
Hypothalamic Hormones / administration & dosage*,  physiology
Injections, Intraventricular
Motor Activity / drug effects,  physiology
Neuropeptides / administration & dosage*,  physiology
Prolactin / secretion*
Prolactin-Releasing Hormone
Rats, Wistar
Reg. No./Substance:
0/Hypothalamic Hormones; 0/Neuropeptides; 0/Prlh protein, rat; 0/Prolactin-Releasing Hormone; 9002-62-4/Prolactin

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