Document Detail

Effect on renal function of essential fatty acid supplementation in cystic fibrosis.
MedLine Citation:
PMID:  2754552     Owner:  NLM     Status:  MEDLINE    
Changes in renal hemodynamics, sodium homeostasis, renal acidifying capacity, and aldosterone excretion were studied before and after long-term intravenous essential fatty acid supplementation for a period of 3 years in 11 patients with cystic fibrosis. The mean (+/- SD) glomerular filtration rate was high at the start of the study (133 +/- 18 ml/min/1.73 m2 body surface area) and decreased significantly (p less than 0.05) to within normal values after 1 year of essential fatty acid supplementation. The urinary elimination of an oral sodium load initially was very low (3.6 +/- 2.5 mmol/hr/1.73 m2 body surface area vs control subjects' values of 7.9 +/- 2.0; p less than 0.001) and increased during treatment but was not normalized (p less than 0.05 vs control subjects' values). Free water clearance and distal tubular sodium delivery, which were significantly decreased before treatment (p less than 0.01 and p less than 0.001 vs control subjects' values, respectively) did not increase significantly. The mean urinary aldosterone excretion did not significantly differ from that in control subjects before and after treatment. The acidifying capacity was disturbed, indicating a low renal bicarbonate threshold, and was changed during treatment in only 2 of 10 patients. These data indicate that essential fatty acid deficiency may contribute to the renal disturbances in cystic fibrosis.
B Strandvik; U Berg; A Kallner; E Kusoffsky
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  115     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-08-29     Completed Date:  1989-08-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  242-50     Citation Subset:  AIM; IM    
Department of Pediatrics, Huddinge University Hospital, Sweden.
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MeSH Terms
Acid-Base Equilibrium
Aldosterone / urine
Child, Preschool
Cystic Fibrosis / physiopathology,  therapy*
Fat Emulsions, Intravenous / therapeutic use
Fatty Acids, Essential / blood,  therapeutic use*
Glomerular Filtration Rate
Kidney / physiopathology*
Kidney Concentrating Ability
Phospholipids / blood
p-Aminohippuric Acid / pharmacokinetics
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Fatty Acids, Essential; 0/Phospholipids; 52-39-1/Aldosterone; 61-78-9/p-Aminohippuric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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