Document Detail


Effect of remote ischaemic preconditioning on ischaemic-reperfusion injury in pulmonary hypertensive infants receiving ventricular septal defect repair.
MedLine Citation:
PMID:  22157844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Remote ischaemic preconditioning (RIPC) can reduce ischaemic-reperfusion injury in distant organs. The myocardial and pulmonary protective effect of RIPC in infants with pulmonary hypertension remains unclear. We conducted a randomized controlled trial to evaluate the effect of RIPC in infants receiving ventricular septal defect (VSD) repair.
METHODS: We studied 55 infants with pulmonary hypertension undergoing VSD repair (RIPC group, n=27; control group, n=28). RIPC consisted of four 5 min cycles of lower limb ischaemia and reperfusion. Serum troponin I (TnI) concentrations were measured after induction of anaesthesia and at 1, 6, 12, and 24 h after surgery. Other clinical data such as inotropic score, lung compliance, alveolar-arterial oxygen gradient, oxygen index, mechanical ventilation time, and length of intensive care unit stay were also recorded at each interval.
RESULTS: No differences in patient or surgical characteristics were observed between the two groups. There were no significant differences in postoperative TnI levels according to time (P=0.35) or the total amount of TnI release, expressed as the area under the curve over the 24 h after surgery [RIPC vs control: 207.6 (134.0) vs 274.6 (263.7) h ng ml(-1), P=0.24]. All other clinical data were also comparable.
CONCLUSIONS: RIPC does not reduce the postoperative TnI release after VSD repair in infants with pulmonary hypertension. Additionally, it is difficult to find significant clinical benefits of RIPC in this population. The effect of RIPC varies according to clinical situation and patient condition.
CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT01313832.
Authors:
J-H Lee; Y-H Park; H-J Byon; H-S Kim; C-S Kim; J-T Kim
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-12-08
Journal Detail:
Title:  British journal of anaesthesia     Volume:  108     ISSN:  1471-6771     ISO Abbreviation:  Br J Anaesth     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-17     Completed Date:  2012-03-09     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  223-8     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT01313832
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, General / methods
Biological Markers / blood
Double-Blind Method
Heart Septal Defects, Ventricular / complications,  surgery*
Humans
Hypertension, Pulmonary / etiology,  surgery
Infant
Intraoperative Care / methods
Ischemic Preconditioning / methods*
Myocardial Reperfusion Injury / prevention & control
Postoperative Complications / prevention & control*
Reperfusion Injury / prevention & control*
Treatment Outcome
Troponin I / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Troponin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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