Document Detail

Effect of remifentanil compared with fentanyl on intraocular pressure after succinylcholine and tracheal intubation.
MedLine Citation:
PMID:  11094598     Owner:  NLM     Status:  MEDLINE    
Rapid sequence induction using succinylcholine is associated with an increase in intraocular pressure (IOP). This may lead to loss of ocular contents in open globe injuries. No method has previously been shown to prevent this increase in IOP. We investigated whether remifentanil, an ultra-short-acting opioid, could attenuate this increase in IOP during rapid sequence induction of anaesthesia. Forty-five patients were randomized blindly to receive remifentanil 1 microgram kg-1, fentanyl 2 micrograms kg-1 or placebo 1 min before thiopental, succinylcholine and tracheal intubation. IOP and haemodynamic variables were measured before, 1 min after the test solution, 30 s after thiopental, 30 s after succinylcholine, immediately after intubation and then every 3 min for 9 min. Remifentanil obtunded the increase in IOP after succinylcholine and intubation, so it could be suitable for use in open globe injuries.
H P Ng; F G Chen; S M Yeong; E Wong; P Chew
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  85     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-30     Completed Date:  2000-11-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  785-7     Citation Subset:  IM    
Department of Anaesthesia, National University Hospital, Singapore, Singapore.
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MeSH Terms
Analgesics, Opioid / therapeutic use*
Double-Blind Method
Fentanyl / therapeutic use
Hemodynamics / drug effects
Intubation, Intratracheal / adverse effects
Middle Aged
Neuromuscular Depolarizing Agents / adverse effects*
Ocular Hypertension / etiology,  prevention & control*
Piperidines / therapeutic use*
Succinylcholine / adverse effects*
Reg. No./Substance:
0/Analgesics, Opioid; 0/Neuromuscular Depolarizing Agents; 0/Piperidines; 132875-61-7/remifentanil; 306-40-1/Succinylcholine; 437-38-7/Fentanyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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