Document Detail

Effect of regulatory peptides on the vagally stimulated lower esophageal sphincter pressure in pigs.
MedLine Citation:
PMID:  3749810     Owner:  NLM     Status:  MEDLINE    
The effect of vasoactive intestinal polypeptide (VIP), enkephalin, neuropeptide Y, gastrin, cholecystokinin, neurotensin, somatostatin, and thyrotropin-releasing hormone on the lower esophageal sphincter pressure (LESP) was studied in anesthetized pigs. The peptides were infused into the arterial supply of the lower esophageal sphincter in graded doses during electrical stimulation of the vagal nerve (9 V, 10 Hz, 3 msec). The vagally stimulated LESP was inhibited by VIP (0-40 pmol/kg/min) and enkephalin (0-200 pmol/kg/min) in a dose-dependent manner. The other peptides had no effect on the stimulated LESP regardless of the dose tested. The results suggest that VIP and enkephalin may influence the stimulated LESP under normal conditions and that the other peptides tested did not affect the physiological regulation of the LESP. Furthermore, the vagally stimulated LESP was inhibited by atropine (250 micrograms/kg intravenously) but not by guanethidine (1 mg/kg intravenously).
S Aggestrup; S L Jensen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  21     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-10-15     Completed Date:  1986-10-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  761-4     Citation Subset:  IM    
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MeSH Terms
Electric Stimulation
Esophagogastric Junction / drug effects*
Models, Biological
Peptides / pharmacology*
Vagus Nerve / physiology
Reg. No./Substance:

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