Document Detail

Effect of regular physical activity on carotid intima-media thickness. Results from a 6-year prospective study in the early stage of hypertension.
MedLine Citation:
PMID:  20977389     Owner:  NLM     Status:  MEDLINE    
AIM: To study the effect of leisure-time physical activity on the progression of carotid intima-media thickness (IMT) in the early stage of hypertension.
METHODS: We studied 47 sedentary and 40 physically active young pre-hypertensive or stage 1 hypertensive subjects. IMT was assessed in the common carotid artery, carotid bulb and internal carotid artery at baseline and after 6.5 years.
RESULTS: Cumulative maximum IMT of the three carotid segments (M-MAX, 0.13 ± 0.08 vs 0.10 ± 0.07 mm, p = 0.006) and cumulative mean IMT (m-IMT, 0.11 ± 0.07 vs 0.09 ± 0.06 mm, p = 0.01), adjusted for confounders, increased to a greater degree in the sedentary than the active subjects. Differences in known risk factors explained a large proportion of the observed association. Inclusion of baseline cholesterol in the regression model attenuated the strength of the association for both M-MAX (p = 0.04) and m-IMT (p = 0.049). When also baseline blood pressure, heart rate, and body mass index were taken into account the association with physical activity status remained significant for maximum IMT of internal carotid artery (p = 0.034) and was of borderline significance for M-MAX (p = 0.066).
CONCLUSIONS: Physical activity can delay the progression of carotid IMT in hypertension. This effect is mediated in substantial part by the better risk factor profile in active subjects.
Paolo Palatini; Massimo Puato; Marcello Rattazzi; Paolo Pauletto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-27
Journal Detail:
Title:  Blood pressure     Volume:  20     ISSN:  1651-1999     ISO Abbreviation:  Blood Press.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-21     Completed Date:  2011-05-31     Revised Date:  2012-03-30    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  England    
Other Details:
Languages:  eng     Pagination:  37-44     Citation Subset:  IM    
Dipartimento di Medicina Clinica e Sperimentale, Università di Padova, Via Giustiniani 2, Padua, Italy.
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MeSH Terms
Biological Markers
Blood Pressure
Body Mass Index
Case-Control Studies
Cholesterol / blood
Disease Progression
Hypertension / physiopathology*
Motor Activity*
Prehypertension / physiopathology*
Prospective Studies
Risk Factors
Tunica Intima / pathology*
Tunica Media / pathology*
Reg. No./Substance:
0/Biological Markers; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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