Document Detail

Effect of recombinant interleukin-5, interleukin-3, and eotaxin on apoptosis in eosinophilic granulocytes.
MedLine Citation:
PMID:  18214283     Owner:  NLM     Status:  MEDLINE    
We studied in vitro effects of recombinant interleukin-5, interleukin-3, and eotaxin on programmed death of eosinophils from healthy donors and patients with non-Hodgkin's lymphomas associated with severe blood eosinophilia. Interleukin-5 and eotaxin produced the most potent antiapoptotic effect on eosinophils from healthy donors. In patients with non-Hodgkin's lymphomas, spontaneous apoptosis in eosinophilic leukocytes was low and remained unchanged during incubation with recombinant proteins.
N V Ryazantseva; V V Novitskii; L S Litvinova; S B Tkachenko; Yu V Kolobovnikova; O B Zhukova; E S Grigor'eva; E V Suvorova; E N Knutareva; T T Radzivil; N Yu Chasovskikh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  143     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2008-01-24     Completed Date:  2008-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  395-8     Citation Subset:  IM    
Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk.
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MeSH Terms
Apoptosis / drug effects*
Case-Control Studies
Cells, Cultured
Chemokines, CC / genetics,  metabolism,  pharmacology*
Eosinophilia / blood
Eosinophils / cytology,  drug effects*
Interleukin-3 / genetics,  metabolism,  pharmacology*
Interleukin-5 / genetics,  metabolism,  pharmacology*
Lymphoma, Non-Hodgkin / blood
Middle Aged
Recombinant Proteins / metabolism,  pharmacology*
Reg. No./Substance:
0/Chemokines, CC; 0/Interleukin-3; 0/Interleukin-5; 0/Recombinant Proteins

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