Document Detail

Effect of recombinant interferon gamma and interleukin-2 and of a monoclonal antibody against interferon gamma on the rat immune response against heart allografts.
MedLine Citation:
PMID:  1906747     Owner:  NLM     Status:  MEDLINE    
We studied the effect of rat rec-IFN-gamma, human rec-IL-2, and an IgG1 monoclonal antibody (DB1) directed against rat IFN-gamma on allograft survival in the rat in various experimental conditions. The DB1 monoclonal antibody did not prolong heart allograft survival in the (LEW/BN)F1 to LEW combination, even when used at high doses (2 mg/rat x 9 days). Rec-IFN-gamma induced major histocompatibility antigen expression in vivo, but its administration had no effect on the graft survival either of untreated LEW recipients of (LEW x BN)F1 heart allografts or of donor blood-transfused LEW recipients. In addition, rec-IFN-gamma alone had no effect on graft survival in cyclosporine-treated rats. In contrast, rec-IL-2 shortened heart allograft survival both in untreated and in cyclosporine-treated recipients. Rec-IFN-gamma partially reversed the effects of rec-IL-2 in cyclosporine-treated rats. The data suggest that in vivo administration of IFN-gamma in allograft recipients may have a suppressor effect, in addition to the postulated augmenting effect on the immune response by increasing MHC antigen expression.
J Paineau; C Priestley; J Fabre; S Chevalier; P van der Meide; H Schellekens; Y Jacques; J P Soulillou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  10     ISSN:  1053-2498     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:    1991 May-Jun
Date Detail:
Created Date:  1991-08-27     Completed Date:  1991-08-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  424-30     Citation Subset:  IM    
INSERM U.211 (Unité de Recherche sur les Effecteurs Lymphocytaires T) Nantes, France.
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MeSH Terms
Antibodies, Monoclonal / therapeutic use*
Cyclosporins / therapeutic use
Graft Rejection / immunology*
Graft Survival / immunology*
Heart Transplantation / immunology*
Histocompatibility Antigens Class I / immunology*
Histocompatibility Antigens Class II / immunology*
Interferon-gamma, Recombinant / therapeutic use*
Interleukin-2 / therapeutic use*
Rats, Inbred Lew
Recombinant Proteins / therapeutic use
Transplantation, Homologous
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Cyclosporins; 0/Histocompatibility Antigens Class I; 0/Histocompatibility Antigens Class II; 0/Interferon-gamma, Recombinant; 0/Interleukin-2; 0/Recombinant Proteins

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