| Effect of recombinant human keratinocyte growth factor (Δ23rHuKGF, Palifermin) on inflammatory and immune changes in mouse tongue during fractionated irradiation. | |
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MedLine Citation:
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PMID: 20636237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: A significant reduction in the incidence of radiation-induced oral mucositis by Palifermin has been demonstrated. The underlying mechanisms, however, remain unclear. The aim of the present study was to assess the effect of Palifermin on inflammatory and immune processes during fractionated irradiation in mouse tongue. MATERIALS AND METHODS: Fractionated irradiation, 10 x 3 Gy in two weeks, was given to the snout of the animals. In one group, a single injection of Palifermin (15 mg/kg, s.c.) was given one day before the onset of radiotherapy. Groups of mice (n = 3) were sacrificed from day 1-16 after the start of irradiation. Vasodilatation, endothelial expression of intercellular adhesion molecule 1 (ICAM-1) and the number of CD105-positive (CD105(+)) macrophages were assessed. RESULTS: Compared to untreated control tissue, irradiation resulted in a significant vasodilatation and an increase in endothelial ICAM-1 staining intensity during the entire study period. Additionally, a significant increase in the number of CD105(+) macrophages was detected. In contrast, with Palifermin treatment before irradiation, none of these changes were found within the first 10 days. CONCLUSION: Palifermin pre-treatment resulted in a long-lasting inhibition of radiation-induced inflammatory and immune changes in mouse tongue. This may contribute to the protective effect of this growth factor. |
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Authors:
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Jana Jaal; Caroline Richter; Wolfgang Dörr |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of radiation biology Volume: 86 ISSN: 1362-3095 ISO Abbreviation: Int. J. Radiat. Biol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-11-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809243 Medline TA: Int J Radiat Biol Country: England |
Other Details:
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Languages: eng Pagination: 860-6 Citation Subset: IM; S |
Affiliation:
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Department of Radiotherapy and Oncological Therapy, Clinic of Haematology and Oncology, Tartu University Hospital, Estonia. Jana.Jaal@kliinikum.ee |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Count Dose Fractionation* Endothelial Cells / drug effects, metabolism, radiation effects Female Fibroblast Growth Factor 7 / pharmacology*, therapeutic use Gene Expression Regulation / drug effects, radiation effects Humans Intercellular Adhesion Molecule-1 / metabolism Intracellular Signaling Peptides and Proteins / metabolism Macrophages / cytology, drug effects, metabolism, radiation effects Mice Radiation Injuries, Experimental / drug therapy, immunology*, metabolism Recombinant Proteins / pharmacology*, therapeutic use Stomatitis / drug therapy, immunology*, metabolism Tongue / blood supply, drug effects*, immunology, radiation effects* Vasodilation / drug effects, radiation effects |
| Chemical | |
Reg. No./Substance:
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0/Intracellular Signaling Peptides and Proteins; 0/Recombinant Proteins; 0/endoglin protein, mouse; 126469-10-1/Fibroblast Growth Factor 7; 126547-89-5/Intercellular Adhesion Molecule-1 |
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