| Effect of recombinant human erythropoietin treatment on hemodynamic parameters in continuous ambulatory peritoneal dialysis and hemodialysis patients. | |
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MedLine Citation:
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PMID: 1481867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the hemodynamic changes and the incidence of hypertension after correction of anemia with recombinant human erythropoietin (rhEPO) in 25 hemodialysis (HD) and in 27 continuous ambulatory peritoneal dialysis (CAPD) patients with a mean age of 44.6 years and a mean time on dialysis of 43.6 months. We analyzed basal and final hemoglobin concentrations, time elapsed to reach target hemoglobin, rhEPO dosage, and the following echocardiographic parameters: left ventricular end-systolic and end-diastolic diameters and volumes, posterior wall thickness, interventricular septum, ejection fraction, fractional fiber shortening, cardiac output index, and peripheral vascular resistance index. We did not find any significant difference between HD and CAPD patients in basal and final hemoglobin, concentrations, time elapsed to reach target hemoglobin, dose of rhEPO received for response, and incidence of hypertension. Changes were more evident in HD patients, with a decrease of 15% in cardiac output index and an equal increase of peripheral vascular resistance,. In the patients on CAPD, these variations were less important, with a decrease in cardiac output index of 10% and no significant change in peripheral vascular resistance. Despite both techniques showing the occurrence of hypertension, the left ventricular mass stabilized during the study time. We conclude that CAPD seems to modulate the changes observed in hemodynamic parameters after rhEPO treatment. |
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Authors:
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A Fernández; N Vega; F Jiménez; M Macía; E Laraudiogoitía; L Hortal; M Perdomo; C Plaza; J C Rodríguez; L Palop |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of nephrology Volume: 12 ISSN: 0250-8095 ISO Abbreviation: Am. J. Nephrol. Publication Date: 1992 |
Date Detail:
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Created Date: 1993-02-09 Completed Date: 1993-02-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 207-11 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Hospital Ntra Sra del Pino, Las Palmas de Gran Canaria, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia / drug therapy*, etiology Blood Pressure / drug effects Echocardiography Erythropoietin / adverse effects*, therapeutic use Hemodynamics / drug effects* Humans Hypertension / chemically induced*, epidemiology Incidence Kidney Failure, Chronic / complications, therapy Peritoneal Dialysis, Continuous Ambulatory* Recombinant Proteins / adverse effects, therapeutic use Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 11096-26-7/Erythropoietin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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