| Effect of recombinant human erythropoietin in preterm infants. | |
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MedLine Citation:
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PMID: 10480285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-five premature infants (mean gestational age+/-SD, 31.4+/-1.9 weeks) were administered subcutaneously recombinant human erythropoietin (rHuEpo) at a dose of 300 u/kg of body weight three times a week beginning on the third day of life and continuing for 6 weeks. The controls (n=23) were premature infants with a mean gestational age of 32.2+/-2.3 weeks who did not receive rHuEpo. Haematological indices, haemoglobin and serum phosphate (Pi), and red blood cell (RBC) phosphate metabolites (ATP, 2,3-DPG, RBCPi) were tested monthly until the 6th month and thereafter at the 9th and 12th months of life. The level of serum soluble transferrin receptors (sTfR) correlated significantly with rHuEpo (p<0.05). The ratio of sTfR to log (ferritin) was significantly higher (p<0.001) in the infants treated with rHuEpo than the controls. Intracellular organic and inorganic Pi changes were not affected by the Epo administration. The RBC 2,3-DPG seemed adequate in infants receiving rHuEpo. |
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Authors:
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N Krallis; V Cholevas; A Mavridis; I Georgiou; K Bourantas; S Andronikou |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: European journal of haematology Volume: 63 ISSN: 0902-4441 ISO Abbreviation: Eur. J. Haematol. Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-09-23 Completed Date: 1999-09-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8703985 Medline TA: Eur J Haematol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 71-6 Citation Subset: IM |
Affiliation:
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Child Health Department, Neonatology Clinic, University of Ioannina, Medical School, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2,3-Diphosphoglycerate
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blood Adenosine Triphosphate / blood Anemia / drug therapy, prevention & control* Energy Metabolism Erythrocytes / metabolism* Erythropoietin / blood Erythropoietin, Recombinant / therapeutic use* Follow-Up Studies Gestational Age Humans Infant, Newborn Infant, Premature* Phosphates / blood* Prospective Studies Receptors, Transferrin / blood Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Erythropoietin, Recombinant; 0/Phosphates; 0/Receptors, Transferrin; 11096-26-7/Erythropoietin; 138-81-8/2,3-Diphosphoglycerate; 56-65-5/Adenosine Triphosphate |
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